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Alkaline Phosphatase

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Definition: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.  /defic: consider also HYPOPHOSPHATASIA   
See Also Hypophosphatasia
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
asfotase alfa  0   *Alkaline Phosphatase *Immunoglobulin G *Recombinant Fusion Proteins Hypophosphatasia/drug therapy Enzyme Replacement Therapy. N Engl J Med. 2012 Mar 8;366(10):904-13
ALPPL2 protein, human  EC 3.1.3.1   *Alkaline Phosphatase GPI-Linked Proteins.
ALPL protein, human  EC 3.1.3.1   *Alkaline Phosphatase.
2,5-dimethoxy-N-(quinolin-3-yl)benzenesulfonamide  0   *Quinolines *Sulfonamides Alkaline Phosphatase/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6919-25
5804079 compound  0   *Imidazoles *Triazines Alkaline Phosphatase/antagonists & inhibitors. J Bone Miner Res 2007 Nov;22(11):1700-10
5361418 compound  0   *Triazoles Alkaline Phosphatase/antagonists & inhibitors. J Bone Miner Res 2007 Nov;22(11):1700-10
5923412 compound  0   *Triazoles Alkaline Phosphatase/antagonists & inhibitors. J Bone Miner Res 2007 Nov;22(11):1700-10
Akp3 protein, mouse  EC 3.1.3.1   *Alkaline Phosphatase. Am J Physiol Gastrointest Liver Physiol 2007 May;292(5):G1439-49
alkaline phosphatase 2, mouse  EC 3.1.3.1   *Alkaline Phosphatase. Proc Natl Acad Sci U S A 1987 Oct;84(20):7051-5
PHO8 protein, S cerevisiae  EC 3.1.3.1   *Alkaline Phosphatase *Saccharomyces cerevisiae Proteins. J Biol Chem 2006 Mar 3;281(9):5539-45
periplasmic alkaline phosphatase, Chryseobacterium meningosepticum  EC 3.1.3.1   *Alkaline Phosphatase *Bacterial Proteins. Microbiology 2001Oct;147(Pt 10)
MUSEAP protein, mouse  EC 3.1.3.1   *Alkaline Phosphatase Genes, Reporter. Gene 2001 Nov 14;279(1):99-108
Akp3 protein, rat  EC 3.1.3.-   *Alkaline Phosphatase *Isoenzymes. Physiol Genomics 2000 Jun 29;3(1):1-8
Alpi protein, rat  EC 3.1.3.-   *Alkaline Phosphatase *Isoenzymes. Physiol Genomics 2000 Jun 29;3(1):1-8
oxodiperoxo(2,2'-bipyridine)vanadate(V)  0   *Organometallic Compounds 2,2'-Dipyridyl/*analogs & derivatives Alkaline Phosphatase/antagonists & inhibitors. J Protein Chem 1999 Oct;18(7):735-40
phoA protein, E coli  EC 3.1.3.1   *Alkaline Phosphatase *Escherichia coli Proteins. EMBO J 1998 Jul 15;17(14):3990-4003
MC14 alkaline phosphatase I  EC 3.1.3.-   *Alkaline Phosphatase. FEMS Microbiol Lett 1998 Feb 1;159(1):47-58
miniplacental alkaline phosphatase  EC 3.1.3.-   *Alkaline Phosphatase *Pregnancy Proteins. Proc Natl Acad Sci U S A 1992 Feb 15;89(4):1350-3
phosphonoacetate hydrolase  EC 3.11.1.2   *Alkaline Phosphatase. Eur J Biochem 1995 Nov 15;234(1):225-30
AttoPhos  142441-49-4 AttoPhos  *Organophosphorus Compounds Alkaline Phosphatase. Biotechniques 1992 Feb:12(2):264-9
ALPI protein, human  EC 3.1.3.1   *Alkaline Phosphatase GPI-Linked Proteins Antigens, Surface Tumor Markers, Biological. Proc Natl Acad Sci USA 1990;87(4):1263
germ-cell AP isoenzyme  0   *Alkaline Phosphatase *Isoenzymes Testis/enzymology Thymus Gland/enzymology Tumor Markers, Biological. Proc Natl Acad Sci USA 1988;85(9):3024
progesterone 11-glucuronide-alkaline phosphatase conjugate  0   *Alkaline Phosphatase *Hydroxyprogesterones. J Reprod Fertil 1986;76(1):375
periodate-oxidized AMP  0   Adenosine Monophosphate/*analogs & derivatives Alkaline Phosphatase/antagonists & inhibitors. Biochem J 1981;199(2):281
alkaline phosphatase, placental  EC 3.1.3.1   *Alkaline Phosphatase *Isoenzymes GPI-Linked Proteins. Ann NY Acad Sci 259:261-354;1975
fosfosal  6064-83-1 Benzoic acid, 2-(phosphonooxy)  *Phosphoric Acid Esters Alkaline Phosphatase/antagonists & inhibitors. Int J Biochem 1980;11(6):511; Z Rechtsmedizin 69(4):259;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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