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Acetylcholinesterase

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Definition: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.  reactivation or reactivators: coord NIM (with no qualif) with CHOLINESTERASE REACTIVATORS (IM)    Other names Hydrolase, Acetylcholine; Acetylthiocholinesterase; Acetylcholine Hydrolase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
asporyergosterol  0   Ergosterol/*analogs & derivatives Acetylcholinesterase. Nat Prod Commun 2010 Oct;5(10):1575-8
9-O-((2-(3-methyl)pyridinium)ethyl)berberine  0   *Pyridinium Compounds Berberine/*analogs & derivatives Acetylcholinesterase Butyrylcholinesterase. Bioorg Med Chem 2010 Jun 15;18(12):4475-84
9-O-(3-(naphthalene-2-ylthio)butyl)berberine  0   Berberine/*analogs & derivatives Acetylcholinesterase Butyrylcholinesterase. Bioorg Med Chem 2010 Jun 15;18(12):4475-84
ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo(b)(1,8)naphthyridine-3-carboxylate  0   *Naphthyridines Acetylcholinesterase. Bioorg Med Chem Lett 2010 May 1;20(9):2950-3
2-norbornyl-N-n-butylcarbamate  0   *Carbamates *Norbornanes Acetylcholinesterase. Chirality 2010 Feb;22(2):267-74
Ache protein, rat  EC 3.1.1.7   *Acetylcholinesterase GPI-Linked Proteins.
Ache protein, mouse  EC 3.1.1.7   *Acetylcholinesterase GPI-Linked Proteins.
ACHE protein, human  EC 3.1.1.7   *Acetylcholinesterase GPI-Linked Proteins.
heterophyllinine B  0   *Alkaloids *Diterpenes Acetylcholinesterase Butyrylcholinesterase. J Enzyme Inhib Med Chem 2009 Feb;24(1):47-51
heterophyllinine A  0   *Alkaloids *Diterpenes Acetylcholinesterase Butyrylcholinesterase. J Enzyme Inhib Med Chem 2009 Feb;24(1):47-51
Colq protein, mouse  EC 3.1.1.7   *Acetylcholinesterase *Collagen *Muscle Proteins. Mol Cell Neurosci. 2008 Nov;39(3):429-38
ColQ protein, rat  EC 3.1.1.7   *Acetylcholinesterase *Collagen. J Biol Chem 1997 Sep 5;272(36):22840-7
bis(12)-hupyridone  0   *Quinolones Acetylcholinesterase. J Pharm Biomed Anal 2008 Jan 7;46(1):75-81
TZ2PA6 compound  0   *Phenanthridines Tacrine/*analogs & derivatives Acetylcholinesterase/antagonists & inhibitors. J Med Chem 2005 Dec 29;48(26):8155-62
(9-amino-5,6,7,8-tetrahydroacridin-4-yl)methanol  0   Tacrine/*analogs & derivatives Acetylcholinesterase/antagonists & inhibitors. J Med Chem 2005 Nov 17;48(23):7496-9
N,N'-(3-methyl)phenylenediaminophosphorylchloridate  0   *Organophosphorus Compounds *Bicyclo Compounds, Heterocyclic Acetylcholinesterase/antagonists & inhibitors. J Enzyme Inhib Med Chem 2004 Oct;19(5):403-7
O,O'-(3-methyl)phenylenediphorylchloride  0   *Organophosphorus Compounds *Bicyclo Compounds, Heterocyclic Acetylcholinesterase/antagonists & inhibitors. J Enzyme Inhib Med Chem 2004 Oct;19(5):403-7
3-methyl-2-(4-methyl-1-piperazinyl)-N-(7-((1,2,3,4-tetrahydroacridin-9-yl)amino)heptyl)quinoline-4-carboxamide  0   *Acridines *Quinolines Acetylcholinesterase/antagonists & inhibitors. J Med Chem 2005 May 19;48(10):3564-75
bis(18)-huperzine B  0   *Bridged Compounds *Pyridones Acetylcholinesterase/antagonists & inhibitors. J Med Chem 2005 Feb 10;48(3):655-7
6-(ethyl-(2-methoxybenzyl)amino)-1-(1'-(6-(ethyl-(2-methoxybenzyl)amino)hexanoyl)-(4,4')bipiperidinyl-1-yl)hexan-1-one  0   *Piperidines Acetylcholinesterase/antagonists & inhibitors. J Med Chem 2004 Dec 16;47(26):6490-8
ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzo(1,8)naphthyridine-3-carboxylate  0   Tacrine/*analogs & derivatives Acetylcholinesterase/antagonists & inhibitors. J Pharmacol Exp Ther 2004 Sep;310(3):987-94
AchE peptide  0   *Acetylcholinesterase *Peptide Fragments. J Neurochem 2004 Jul;90(2):325-31
14-norhuperzine A  0   *Sesquiterpenes Acetylcholinesterase/antagonists & inhibitors. Yao Xue Xue Bao 2003 May;38(5):346-9
AP 2238  0   *Benzylamines *Coumarins Acetylcholinesterase/antagonists & inhibitors. J Med Chem 2003 Jun 5;46(12):2279-82
3-hydroxy-2-oxoindole  61-71-2   *Indoles Acetylcholinesterase/antagonists & inhibitors Monoamine Oxidase/antagonists & inhibitors. Eur J Biochem 2001 Nov;268(22):5755-63
ungiminorine  0   *Amaryllidaceae Alkaloids Acetylcholinesterase. J Nat Prod 2000 Jun;63(6):803-6
1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine  0   Tacrine/*analogs & derivatives Acetylcholinesterase. Chung Kuo Yao Li Hsueh Pao 1999 Mar;20(3):211-7
COLQ protein, human  EC 3.1.1.7   *Acetylcholinesterase *Collagen *Muscle Proteins. Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9654-9
RH 218  38524-82-2   *Thiophosphoric Acid Esters Acetylcholinesterase/antagonists & inhibitors. J Environ Sci Health (B) 1981;16(4):475
phosphonylated acetylcholinesterase  EC 3.1.1.-   *Acetylcholinesterase. Eur J Biochem 100(2):527;1979; Sb Ved Pr Lek Fak Univ Karlovy 19(5):581;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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