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Histone Demethylases

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Definition: Enzymes that catalyse the removal of methyl groups from LYSINE or ARGININE residues found on HISTONES. Many histone demethylases generally function through an oxidoreductive mechanism.     
Examples Jumonji Domain-Containing Histone Demethylases 		Other names Lysine Demethylases, Histone; Demethylases, Histone Lysine; Demethylases, Histone Arginine; Demethylases, Histone; Arginine Demethylases, Histone; Histone Lysine Demethylases; Histone Arginine Demethylases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
JMJD2A protein, mouse  EC 1.14.11.-   *Histone Demethylases. J Clin Invest 2011 Jun 1;121(6):2447-56
LSD1 protein, rat  EC 1.14.11.-   *Histone Demethylases. Neurosci Res 2010 Sep;68(1):66-72
KIAA1718 protein, mouse  EC 1.14.11.-   *Histone Demethylases. Genes Cells 2010 Aug;15(8):867-73
PHF8 protein, mouse  EC 1.14.11.27   *Transcription Factors *Histone Demethylases. Cell Res. 2010 Aug;20(8):908-18
PHF8 protein, zebrafish  EC 1.14.11.-   *Transcription Factors *Zebrafish Proteins *Histone Demethylases. Nature. 2010 Jul 22;466(7305):503-7
KDM8 protein, human  EC 1.14.11.-   *Histone Demethylases. Proc Natl Acad Sci U S A 2010 May 25;107(21):9671-6
KDM4A protein, Drosophila  EC 1.5.-   *Drosophila Proteins *Histone Demethylases. Mol Cell 2008 Dec 5;32(5):696-706
UTX protein, human  EC 1.14.11.-   *Nuclear Proteins *Histone Demethylases. Science 2007 Oct 19;318(5849):447-50
PHF8 protein, human  EC 1.14.11.-   *Transcription Factors *Histone Demethylases Mental Retardation, X-Linked. J Med Genet 2005 Oct;42(10):780-6
KDM1A protein, human  EC 1.5.-   *Histone Demethylases. Cell 2004 Dec 29;119(7):941-53
GIS1 protein, S cerevisiae  EC 1.14.11.-   *Saccharomyces cerevisiae Proteins *Histone Demethylases. Mol Cell Biol 1999 Nov;19(11):7630-8
RPH1 protein, S cerevisiae  0   *Repressor Proteins *Saccharomyces cerevisiae Proteins *Histone Demethylases. Mol Cell Biol 1999 Nov;19(11):7630-8
KDM5D protein, human  EC 1.14.11.-   *Histone Demethylases. Science 1995 Sep 15;269(5230):1588-90

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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