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Ceramidases

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Definition: Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.     
Examples Acid Ceramidase; Alkaline Ceramidase; Neutral Ceramidase 		Other names N Acylsphingosine Amidohydrolase; Deacylase, Acylsphingosine; Amidohydrolase, N-Acylsphingosine; N-Acylsphingosine Amidohydrolase; Ceramidase; Acylsphingosine Deacylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivalamide  0   *Amides *Fatty Acids, Unsaturated Ceramidases/antagonists & inhibitors. Prostate. 2011 Jul;71(10):1064-73
ceramidastin  0   *Maleic Anhydrides *Cyclooctanes Ceramidases/antagonists & inhibitors. J Antibiot (Tokyo) 2009 Feb;62(2):63-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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