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Protein Tyrosine Phosphatase, Non-Receptor Type 2

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Definition: A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1. Alternative splicing of the mRNA for this phosphatase results in the production at two gene products, one of which includes a C-terminal nuclear localization domain that may be involved in the transport of the protein to the CELL NUCLEUS. Although initially referred to as T-cell protein tyrosine phosphatase the expression of this subtype occurs widely.      Other names T Cell Protein Tyrosine Phosphatase; Protein Tyrosine Phosphatase, Non Receptor Type 2; TCPTP Enzyme; TC48 Protein Tyrosine Phosphatase; TC48 Enzyme; TC45 Protein Tyrosine Phosphatase; TC45 Enzyme; TC-PTP; T-Cell Protein Tyrosine Phosphatase; Protein Tyrosine Phosphatase, Non-Receptor Type 2,; Protein Tyrosine Phosphatase, Non-Receptor Type 2,
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ptpn2 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatase, Non-Receptor Type 2.
Ptpn2 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatase, Non-Receptor Type 2.
PTPN2 protein, human  EC 3.1.3.48   *Protein Tyrosine Phosphatase, Non-Receptor Type 2.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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