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Complement C3b Inactivator Proteins

More information in Books or onNLM PubMed
Definition: Endogenous proteins that inhibit or inactivate COMPLEMENT C3B. They include COMPLEMENT FACTOR H and COMPLEMENT FACTOR I (C3b/C4b inactivator). They cleave or promote the cleavage of C3b into inactive fragments, and thus are important in the down-regulation of COMPLEMENT ACTIVATION and its cytolytic sequence.  DF: C3B INACT   
Pharmacological Action Complement Inactivating Agents
Examples Complement Factor H; Complement Factor I 		Other names Inhibitors, Complement 3b; Inhibitors, C3b; Inactivators, Complement C3b; Inactivators, Complement 3b; Inactivators, C3b; Factors, Conglutinogen Activating; Conglutinogen Activating Factors; Complement C3b Inhibitor Proteins; Complement C3b Inactivators; Complement 3b Inhibitors; Complement 3b Inactivators; C3b Inhibitors; C3b Inactivators
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CFHR1 protein, human  0   *Complement C3b Inactivator Proteins. PLoS Med 2006 Oct;3(10):e431
serine proteinase P-57  EC 3.4.21.-   *Serine Endopeptidases Complement C3b Inactivator Proteins. Biochem Biophys Res Commun 1986;140(3):1113
C3bINA  0   *Complement C3b Inactivator Proteins. Pediatr Res 1981;15(4):PT 1:362

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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