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Diacylglycerol O-Acyltransferase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyses the last step of the TRIACYLGLYCEROL synthesis reaction in which diacylglycerol is covalently joined to LONG-CHAIN ACYL COA to form triglyceride. It was formerly categorized as EC 2.3.1.124.      Other names Palmitoyl Coenzyme A sn 1,2 Diacylglycerol Acyltra; Palmitoyl CoA sn 1,2 Diacylglycerol Acyltransferas; O-Acyltransferase, Diacylglycerol; O-Acyltransferase 1, Diacylglycerol; Diacylglycerol O Acyltransferase 1; Diacylglycerol O Acyltransferase; Acyltransferase, Palmitoyl-Coenzyme A-sn-1,2-Diacy; Acyltransferase, Palmitoyl-CoA-sn-1,2-Diacylglycer; Acyltransferase, Diglyceride; Acyltransferase, Diacylglycerol; Acyltransferase 1, Diglyceride; Acyl Coenzyme A Diacyl glycerol Acyltransferase; A-sn-1,2-Diacylglycerol Acyltransferase, Palmitoyl; Palmitoyl-Coenzyme A-sn-1,2-Diacylglycerol Acyltra; Palmitoyl-CoA-sn-1,2-Diacylglycerol Acyltransferas; Diglyceride Acyltransferase 1; Diglyceride Acyltransferase; Diacylglycerol O-Acyltransferase 1; Diacylglycerol Acyltransferase; DAGAT Enzyme
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(2-(((1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)carbonyl)amino)ethyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide  0   *Pyrazoles Niacinamide/*analogs & derivatives Diacylglycerol O-Acyltransferase/antagonists & inhibitors. Eur J Pharmacol 2011 Jan 15;650(2-3):663-72
H128 compound  0   *Biphenyl Compounds *Phenylurea Compounds Diacylglycerol O-Acyltransferase/antagonists & inhibitors. Acta Pharmacol Sin 2010 Nov;31(11):1470-7
(IR,2R)-2-(4'-(3-phenyl-ureido)-biphenyl-4-carbonyl)cyclopentanecarboxylic acid  0   *Biphenyl Compounds *Phenylurea Compounds Diacylglycerol O-Acyltransferase/antagonists & inhibitors. J Pharmacol Exp Ther. 2009 Aug;330(2):526-31
(4-(4-(4-amino-7,7-dimethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)phenyl)bicyclo(2.2.2)oct-1-yl)acetic acid  0   *Oxazines *Pyrimidines Diacylglycerol O-Acyltransferase/antagonists & inhibitors. J Med Chem 2009 Mar 26;52(6):1558-68
Dgat2 protein, rat  EC 2.3.1.20   *Diacylglycerol O-Acyltransferase. J Biol Chem 2007 Aug 3;282(31):22678-88
DGAT2 protein, mouse  EC 2.3.1.20   *Diacylglycerol O-Acyltransferase. J Biol Chem 2001 Oct 19;276(42):38870-6
XP 620  0   *Heterocyclic Compounds, 1-Ring Diacylglycerol O-Acyltransferase/antagonists & inhibitors. Biochim Biophys Acta 2005 Oct 15;1737(1):76-82
DGAT2 protein, human  EC 2.3.1.20   *Diacylglycerol O-Acyltransferase.
Dgat1 protein, rat  EC 2.3.1.20   *Diacylglycerol O-Acyltransferase.
Dgat1 protein, mouse  EC 2.3.1.20   *Diacylglycerol O-Acyltransferase.
DGAT1 protein, human  EC 2.3.1.20   *Diacylglycerol O-Acyltransferase.
DGA1 protein, S cerevisiae  EC 2.3.1.20   *Saccharomyces cerevisiae Proteins *Diacylglycerol O-Acyltransferase.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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