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Mannose-Binding Protein-Associated Serine Proteases

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Definition: Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.  see SCR for organism-specific terms   
Pharmacological Action Immunologic Factors 		Other names MASPs; Serine Proteases, MBL-Associated; Serine Protease, MBP-Associated; Protein, MASP-Related; Proteases, MASP; Mannose Binding Protein Associated Serine Protease; Mannan Binding Lectin Serine Proteases; MBP Associated Serine Protease Related Protein; MBP Associated Serine Protease; MBL Associated Serine Proteases; MASP Related Protein; Mannose-Binding Protein-Associated Serine Protease; Mannan-Binding Lectin Serine Proteases; MBP-Associated Serine Protease-Related Protein; MBP-Associated Serine Protease; MBL-Associated Serine Proteases; MASP-Related Protein; MASP Proteases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MASP-1 protein, rat  EC 3.4.21.-   *Mannose-Binding Protein-Associated Serine Proteases. Structure. 2011 Nov 9;19(11):1635-43
MASP-2 protein, mouse  EC 3.4.21.-   *Mannose-Binding Protein-Associated Serine Proteases.
MASP-2 protein, rat  EC 3.4.21.-   *Mannose-Binding Protein-Associated Serine Proteases.
MASP-3 protein, mouse  EC 3.4.21.-   *Mannose-Binding Protein-Associated Serine Proteases. Blood 2002 Nov 1;100(9):3233-9
MASP2 protein, human  EC 3.4.21.-   *Mannose-Binding Protein-Associated Serine Proteases. EMBO J 2003 May 15;22(10):2348-59; Nature 1997 Apr 3;386(6624):506-10
MASP1 protein, human  EC 3.4.21.-   *Mannose-Binding Protein-Associated Serine Proteases. Biochem Biophys Res Commun 1993 Oct 29;196(2):1003-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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