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Tumor Necrosis Factors

More information in Books or onNLM PubMed
Definition: A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.     
Examples Antigens, CD70; B-Cell Activating Factor; 4-1BB Ligand; CD30 Ligand; CD40 Ligand; Ectodysplasins; Fas Ligand Protein; Lymphotoxin-alpha; Lymphotoxin alpha1, beta2 Heterotrimer; Lymphotoxin-beta; OX40 Ligand; RANK Ligand; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor Ligand Superfamily Member 13; Tumor Necrosis Factor Ligand Superfamily Member 14; Tumor Necrosis Factor Ligand Superfamily Member 15 		Other names Receptor Ligands, TNF; Necrosis Factors, Tumor; Tumor Necrosis Factor Superfamily Ligands; TNF Receptor Ligands
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
C1qTNF6 protein, human  0   *Tumor Necrosis Factors. Anal Cell Pathol (Amst) 2011;34(3):113-21
M-sec protein, mouse  0   *Tumor Necrosis Factors. Nat Cell Biol 2009 Dec;11(12):1427-32
C1QTNF3 protein, human  0   *Tumor Necrosis Factors Adiponectin. FEBS Lett 2005 Oct 24;579(25):5565-70
Tnfsf4 protein, rat  0   *Membrane Glycoproteins *Tumor Necrosis Factors Ligands Antigens, CD27.
Tnfsf4 protein, mouse  0   *Membrane Glycoproteins *Tumor Necrosis Factors Ligands Antigens, CD27.
TWEAK protein, rat  0   *Membrane Proteins *Tumor Necrosis Factors *Apoptosis Regulatory Proteins Encephalomyelitis, Autoimmune, Experimental. J Neuroimmunol. 2005 Feb;159(1-2):55-65
Tnfsf12 protein, mouse  0   *Tumor Necrosis Factors Ligands Apoptosis.
TNFSF18 protein, human  0   *Tumor Necrosis Factors. Biochem Biophys Res Commun 2003 Oct 17:310(2):433-8
Tnfsf18 protein, mouse  0   *Tumor Necrosis Factors Ligands. Biochem Biophys Res Commun 2003 Oct 17:310(2):433-8
TNFSF12 protein, human  0   *Tumor Necrosis Factors Ligands Apoptosis. J Biol Chem 1997 Dec 19;272(51):32401-10

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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