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Metalloproteases

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Definition: Proteases which use a metal, normally ZINC, in the catalytic mechanism. This group of enzymes is inactivated by metal CHELATORS.  GEN; prefer specifics   
Examples Metalloendopeptidases; Metalloexopeptidases 		Other names Metallopeptidases; Metalloproteinases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ammodytagin, Vipera ammodytes ammodytes  EC 3.4.-   *Viper Venoms *Metalloproteases. Toxicon. 2011 Nov;58(6-7):570-82
Zmp1 protein, Mycobacterium tuberculosis  EC 3.4.-   *Bacterial Proteins *Metalloproteases. Cell Host Microbe. 2008 Apr 17;3(4):224-32.
NAS-36 protein, C elegans  EC 3.4.-   *Caenorhabditis elegans Proteins *Metalloproteases. Parasitology 2011 Feb;138(2):237-48
porthidin-1, Porthidium lansbergii hutmanni  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Toxicon. 2011 Mar 15;57(4):608-18
presenilins-associated rhomboid-like protein, rat  EC 3.4.-   *Mitochondrial Proteins *Metalloproteases. Endocrine 2009 Dec;36(3):524-9
Batx-I, Bothrops atrox  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Toxicon. 2010 Nov;56(6):936-43
LasA protein, Pseudomonas aeruginosa  EC 3.4.-   *Virulence Factors *Metalloproteases Bacterial Proteins. J Mol Biol 2010 Mar 5;396(4):908-23
FtsH5 protein, Arabidopsis  EC 3.4.-   *Arabidopsis Proteins *Metalloproteases Membrane Proteins. Plant Physiol 2009 Dec;151(4):1790-801
ZHE1 protein, zebrafish  EC 3.4.-   *Zebrafish Proteins *Metalloproteases. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Oct 1;65(Pt 10):1018-20
CG11864 protein, Drosophila  EC 3.4.-   *Drosophila Proteins *Metalloproteases. J Hered 2009 Jul-Aug;100(4):399-410
HF3 protein, Bothrops jararaca  EC 3.4.24.-   *Crotalid Venoms *Metalloproteases. Toxicon. 2009 Jun;53(7-8):797-801
hellerase, Crotalus oreganus helleri  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Comp Biochem Physiol C Toxicol Pharmacol 2009 Apr;149(3):307-16
SEVA TB ES-31 antigen, Mycobacterium tuberculosis  EC 3.4.21.-   *Antigens, Bacterial *Serine Endopeptidases Bacterial Proteins Glycoproteins Metalloproteases. Int J Tuberc Lung Dis 2005 Aug;9(8):915-9
albolatin, Trimeresurus albolabris  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Toxicon 2007 Dec 15;50(8):1192-200
crotarhagin, Crotalus horridus horridus  EC 3.4.24.-   *Crotalid Venoms *Metalloproteases. Thromb Haemost 2007 Dec;98(6):1285-90
FtsH1 protein, Toxoplasma gondii  EC 3.4.24.-   *Membrane Proteins *Metalloproteases. Traffic 2007 Nov;8(11):1543-53
YggG protein, E coli  EC 3.4.-   *Escherichia coli Proteins *Metalloproteases. FEMS Microbiol Lett 2007 Oct;275(1):8-15
FtsH1 protein, Arabidopsis  EC 3.4.-   *Arabidopsis Proteins *Metalloproteases Protein Subunits. Plant J 2007 Oct;52(2):309-21
kistomin protein, Calloselasma rhodostoma  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Mol Pharmacol 2007 Oct;72(4):984-92
ammodytase, Vipera ammodytes ammodytes  EC 3.4.-   *Viper Venoms *Metalloproteases. Toxicon 2007 May;49(6):833-42
Fxna protein, rat  0   *Membrane Proteins *Metalloproteases. Development 2007 Mar;134(5):945-57
patagonfibrase, Philodryas patagoniensis  EC 3.4.-   *Snake Venoms *Metalloproteases. Biochim Biophys Acta 2007 May;1770(5):810-9
ATP23 protein, S cerevisiae  EC 3.4.-   *Saccharomyces cerevisiae Proteins *Metalloproteases Mitochondrial Proteins. Mol Biol Cell 2007 Feb;18(2):617-26
PARL protein, mouse  EC 3.4.21.105   *Mitochondrial Proteins *Metalloproteases Membrane Proteins. Cell 2006 Jul 14;126(1):163-75
ulilysin, Methanosarcina acetivorans  EC 3.4.-   *Metalloproteases. J Biol Chem 2006 Jun 30;281(26):17920-8
cotiaractivase, Bothrops cotiara  0   *Crotalid Venoms Metalloproteases. Biochim Biophys Acta 2006 May;1764(5):863-71
atrahagin  EC 3.4.-   *Reptilian Proteins *Metalloproteases Cobra Venoms. Int J Biochem Cell Biol. 2006;38(4):510-20
FtsH11 protein, Arabidopsis  EC 3.4.-   *Arabidopsis Proteins *Metalloproteases Membrane Proteins Mitochondrial Proteins. Plant Mol Biol 2005 Sep;59(2):239-52
FtsH4 protein, Arabidopsis  EC 3.4.-   *Arabidopsis Proteins *Metalloproteases Membrane Proteins Mitochondrial Proteins. Plant Mol Biol 2005 Sep;59(2):239-52
Csn5 protein, S pombe  EC 3.4.24.-   *Schizosaccharomyces pombe Proteins *Metalloproteases. Science 2002 Oct 18;298(5593):608-11
insularinase A, Bothrops insularis  EC 3.4.-   *Crotalid Venoms *Metalloproteases Prothrombin/agonists. Biol Chem 2005 Jun;386(6):589-600
AMMP protein, Armillaria mellea  EC 3.4.-   *Metalloproteases. Protein Expr Purif 2005 Sep;43(1):10-7
FtsH6 protein, Arabidopsis  EC 3.4.-   *Arabidopsis Proteins *Metalloproteases. Proc Natl Acad Sci U S A 2005 Sep 20;102(38):13699-704
AMZ2 protein, human  EC 3.4.-   *Metalloproteases. J Biol Chem 2005 Aug 26;280(34):30367-75
AMZ1 protein, human  EC 3.4.-   *Metalloproteases. J Biol Chem 2005 Aug 26;280(34):30367-75
CYM1 protein, S cerevisiae  EC 3.4.-   *Saccharomyces cerevisiae Proteins *Metalloproteases. Eur J Biochem 2004 Dec;271(23-24):4788-97
C9orf3 protein, human  EC 3.4.11.-   *Aminopeptidases Metalloproteases. J Biol Chem 2005 Apr 8;280(14):14310-7
EGY1 protein, Arabidopsis  EC 3.4.-   *Arabidopsis Proteins *Metalloproteases Membrane Proteins. Plant J 2005 Feb;41(3):364-75
EmpA protein, Vibrio anguillarum  EC 3.4.-   *Bacterial Proteins *Metalloproteases. BMC Microbiol 2004 Oct 29;4(1):42
bothrostatin, Bothrops jararaca  EC 3.4.-   *Disintegrins *Metalloproteases. Biochem Biophys Res Commun 2005 Apr 8;329(2):457-64
Kul protein, Drosophila  EC 3.4.24.-   *Drosophila Proteins *Metalloproteases. Development 2005 Jan;132(1);123-32
NAS-37 protein, C elegans  EC 3.4.-   *Caenorhabditis elegans Proteins *Metalloproteases. Development 2004 Dec;131(23):6001-8
agkislysin, Agkistrodon acutus  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Biochem Biophys Res Commun 2004 Nov 5;324(1):224-30
Mde10 protein, S pombe  EC 3.4.-   *Schizosaccharomyces pombe Proteins *Metalloproteases Membrane Glycoproteins. Eukaryot Cell 2004 Feb;3(1):27-39
triflamp, Trimeresurus flavoviridis  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Thromb Haemost 2004 Feb;91(2);315-24
Astl protein, mouse  EC 3.4.-   *Metalloproteases. J Biol Chem 2004 Jun 18;279(25):26627-34
ASTL protein, human  EC 3.4.24.21   *Metalloproteases. J Biol Chem 2004 Jun 18;279(25):26627-34
PARL protein, human  EC 3.4.21.105   *Mitochondrial Proteins *Metalloproteases Membrane Proteins. J Alzheimers Dis 2001 Apr;3(2):181-90
laeverin, human  EC 3.4.-   *Metalloproteases. Biochem Biophys Res Commun 2004 Jan 23;313(4);962-8
camelysin, Bacillus cereus  EC 3.4.-   *Metalloproteases Zinc. Infect Immun 2004 Jan;72(1);219-28
Oma1 protein, S cerevisiae  EC 3.4.-   *Saccharomyces cerevisiae Proteins *Metalloproteases Membrane Proteins Mitochondrial Proteins. J Biol Chem 2003 Nov 21;278(47):46414-23
brevilysin H6 protein, Gloydius halys brevicaudus  EC 3.4.24.-   *Calcium-Binding Proteins *Venoms *Metalloproteases. J Biochem (Tokyo). 2000 Aug;128(2):167-73
crovidisin protein, Crotalus viridis  EC 3.4.-   *Carrier Proteins *Reptilian Proteins *Metalloproteases Crotalid Venoms. Arch Biochem Biophys 1997 Jan 15;337(2):291-9
collagenase activator protein, Bos taurus  0   *Metalloproteases Enzyme Activation Peptide Hydrolases Collagenases. Arch Biochem Biophys 1986;251(2):715
aminoacylase I  EC 3.5.1.14   *Amidohydrolases Metalloproteases. Acta Biochim Biophys Acad Sci Hung 12:399;1977; Biotechnol Bioeng 19(3):311;1977; Biotechnol Bioeng 31(3):477;1979; Chem Pharm Bull 26(9):2698;1978; Clin Chim Acta 63(3):263;1975; Clin Chim Acta 84(1/2):27;1978; FEBS Lett 95(2):281;1978; Hoppe Seylers Z Physiol Chem 356(6):921;1975; Methods Enzymol 44:746;1976; Somatic Cell Genet 5(1):11;1979; Z Med Lab Diagn 19(4):206;1978; Z Naturforsch (C) 32(9/10):769;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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