encyclopedia of medical concepts
ψ
ψ
ψ
ψ
Receptor, Melanocortin, Type 4
More information
in Books
or on
Definition
: A melanocortin receptor subtype found primarily in BRAIN. It shows specificity for ALPHA-MSH; BETA-MSH and ADRENOCORTICOTROPIC HORMONE.
Other names
Receptor, Melanocortin 4; Receptor, MC4; Receptor 4, Melanocortin; Receptor, Melanocortin-
4; Melanocortin-
4 Receptor; Melanocortin 4 Receptor; MC4 Receptor; Melanocortin Receptor 4
Substance
CAS Registry & name
Categories
Source
Drugs
*
butir-
His-
Phe-
Arg-
Trp-
Sar-
NH2
0
*Peptides
Receptor, Melanocortin, Type 4/agonists.
Crit Care Med 2011 May;39(5):1089-96
IRC 022511
0
*Melanocortins
Receptor, Melanocortin, Type 4/agonists.
J Endocrinol 2010 Nov;207(2):177-83
IRC 022493
0
*Melanocortins
Receptor, Melanocortin, Type 4/agonists.
J Endocrinol 2010 Nov;207(2):177-83
1-
((1-
tert-
butyl-
4-
(2,4-
difluorophenyl)pyrrolidin-
3-
yl)carbonyl)-
3,5-
dimethyl-
4-
phenylpiperidin-
4-
ol
0
*Piperidines
*Pyrrolidines
Receptor, Melanocortin, Type 4/agonists.
J Med Chem 2010 Apr 22;53(8):3183-97
N-
1-
(2-
(1-
(tert-
butyl-
4-
(2,4-
difluorophenyl)pyrrolidin-
3-
yl)-
5-
chlorophenyl)ethyl)acetamide
0
*Acetamides
*Pyrrolidines
Receptor, Melanocortin, Type 4/agonists.
Clin Pharmacol Ther 2009 Dec;86(6):659-66
1-
(2-
((1-
amino-
1,2,3,4-
tetrahydronaphthalen-
2-
yl)carbonylamino)-
3-
(4-
chlorophenyl)propanoyl)-
N-
(tert-
butyl)-
4-
cyclohexylpiperidine-
4-
carboxamide
0
*Piperidines
1-Naphthylamine/*analogs & derivatives
Receptor, Melanocortin, Type 4/agonists.
Xenobiotica 2008 Nov;38(11):1437-51
N-
(1-
(2-
(4-
(2-
methyl-
3-
(4-
chlorophenyl)propionyl)-
1-
piperazinyl)-
5-
chlorophenyl)-
3-
methylbutyl)-
3-
(dimethylamino)propionamide
0
*Amides
*Piperazines
Receptor, Melanocortin, Type 4/antagonists & inhibitors.
J Med Chem 2007 Dec 13;50(25):6356-66
1-
(2-
(1-
(3-
dimethylaminopropionyl)amino-
2-
methylpropyl)-
4-
methylphenyl)-
4-
(2-
methyl-
3-
(4-
chlorophenyl)propionyl)piperazine
0
*Piperazines
beta-Alanine/*analogs & derivatives
Receptor, Melanocortin, Type 4/antagonists & inhibitors.
J Med Chem 2007 Nov 1;50(22):5249-52
4-
((3-
aminopropionylamido)-
3-
(2,4-
dichlorophenyl)propionyl)-
1-
(2-
((2-
thienyl)ethylaminomethyl)phenyl)piperazine
0
*Piperazines
*Thiophenes
Receptor, Melanocortin, Type 4/antagonists & inhibitors.
J Med Chem 2004 Dec 30;47(27):6821-30
2-
(2-
(2-
(5-
bromo-
2-
methoxyphenyl)ethyl)-
3-
fluorophenyl)-
4,5-
dihydro-
1H-
imidazole
0
*Imidazoles
Receptor, Melanocortin, Type 4/antagonists & inhibitors.
J Med Chem 2004 Mar 25;47(7):1602-4
bremelanotide
0
*alpha-MSH
*Peptides, Cyclic
Receptor, Melanocortin, Type 3
Receptor, Melanocortin, Type 4.
Ann N Y Acad Sci. 2003 Jun;994():96-102; J Sex Med. 2006 Jul;3(4):628-38
MC4R protein, human
0
*Receptor, Melanocortin, Type 4.
melanocortin 4 receptor protein, zebrafish
0
*Zebrafish Proteins
*Receptor, Melanocortin, Type 4.
J Neurochem 2002 Jul;82(1):6-18