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Receptor, Melanocortin, Type 4

More information in Books or onNLM PubMed
Definition: A melanocortin receptor subtype found primarily in BRAIN. It shows specificity for ALPHA-MSH; BETA-MSH and ADRENOCORTICOTROPIC HORMONE.      Other names Receptor, Melanocortin 4; Receptor, MC4; Receptor 4, Melanocortin; Receptor, Melanocortin-4; Melanocortin-4 Receptor; Melanocortin 4 Receptor; MC4 Receptor; Melanocortin Receptor 4
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
butir-His-Phe-Arg-Trp-Sar-NH2  0   *Peptides Receptor, Melanocortin, Type 4/agonists. Crit Care Med 2011 May;39(5):1089-96
IRC 022511  0   *Melanocortins Receptor, Melanocortin, Type 4/agonists. J Endocrinol 2010 Nov;207(2):177-83
IRC 022493  0   *Melanocortins Receptor, Melanocortin, Type 4/agonists. J Endocrinol 2010 Nov;207(2):177-83
1-((1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)carbonyl)-3,5-dimethyl-4-phenylpiperidin-4-ol  0   *Piperidines *Pyrrolidines Receptor, Melanocortin, Type 4/agonists. J Med Chem 2010 Apr 22;53(8):3183-97
N-1-(2-(1-(tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)-5-chlorophenyl)ethyl)acetamide  0   *Acetamides *Pyrrolidines Receptor, Melanocortin, Type 4/agonists. Clin Pharmacol Ther 2009 Dec;86(6):659-66
1-(2-((1-amino-1,2,3,4-tetrahydronaphthalen-2-yl)carbonylamino)-3-(4-chlorophenyl)propanoyl)-N-(tert-butyl)-4-cyclohexylpiperidine-4-carboxamide  0   *Piperidines 1-Naphthylamine/*analogs & derivatives Receptor, Melanocortin, Type 4/agonists. Xenobiotica 2008 Nov;38(11):1437-51
N-(1-(2-(4-(2-methyl-3-(4-chlorophenyl)propionyl)-1-piperazinyl)-5-chlorophenyl)-3-methylbutyl)-3-(dimethylamino)propionamide  0   *Amides *Piperazines Receptor, Melanocortin, Type 4/antagonists & inhibitors. J Med Chem 2007 Dec 13;50(25):6356-66
1-(2-(1-(3-dimethylaminopropionyl)amino-2-methylpropyl)-4-methylphenyl)-4-(2-methyl-3-(4-chlorophenyl)propionyl)piperazine  0   *Piperazines beta-Alanine/*analogs & derivatives Receptor, Melanocortin, Type 4/antagonists & inhibitors. J Med Chem 2007 Nov 1;50(22):5249-52
4-((3-aminopropionylamido)-3-(2,4-dichlorophenyl)propionyl)-1-(2-((2-thienyl)ethylaminomethyl)phenyl)piperazine  0   *Piperazines *Thiophenes Receptor, Melanocortin, Type 4/antagonists & inhibitors. J Med Chem 2004 Dec 30;47(27):6821-30
2-(2-(2-(5-bromo-2-methoxyphenyl)ethyl)-3-fluorophenyl)-4,5-dihydro-1H-imidazole  0   *Imidazoles Receptor, Melanocortin, Type 4/antagonists & inhibitors. J Med Chem 2004 Mar 25;47(7):1602-4
bremelanotide  0   *alpha-MSH *Peptides, Cyclic Receptor, Melanocortin, Type 3 Receptor, Melanocortin, Type 4. Ann N Y Acad Sci. 2003 Jun;994():96-102; J Sex Med. 2006 Jul;3(4):628-38
MC4R protein, human  0   *Receptor, Melanocortin, Type 4.
melanocortin 4 receptor protein, zebrafish  0   *Zebrafish Proteins *Receptor, Melanocortin, Type 4. J Neurochem 2002 Jul;82(1):6-18

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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