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alpha Karyopherins

More information in Books or onNLM PubMed
Definition: Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.     
See Also Nuclear Localization Signals 		Other names receptor, NLS; Karyopherins, alpha; Nuclear Localization Signal-Binding Protein; Nuclear Localization Sequence Receptor; NLSBP; NLS-Binding Protein; NLS Receptor; Karyopherin alpha; Importin-alpha
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
importin alpha4, mouse  0   *alpha Karyopherins. FASEB J. 2011 Nov;25(11):3958-65.
KPNA6 protein, mouse  0   *alpha Karyopherins. Mol Cell Biol. 2011 May;31(9):1800-11
Kpna7 protein, mouse  0   *alpha Karyopherins. J Biol Chem. 2010 Oct 22;285(43):33113-22
KPNA1 protein, mouse  0   *alpha Karyopherins. Nat Cell Biol 2007 Dec;9(12):1337-8
importin alpha 3, mouse  0   *alpha Karyopherins. FEBS Lett 1997 Oct 13;416(1):30-4
Cut15 protein, S pombe  0   *alpha Karyopherins *Schizosaccharomyces pombe Proteins. Genetics 2005 Sep;171(1):7-21
Imp1 protein, S pombe  0   *alpha Karyopherins *Schizosaccharomyces pombe Proteins. Genetics 2005 Sep;171(1):7-21
KPNA6 protein, human  0   *alpha Karyopherins. Mol Cell Biol 2004 Dec;24(23):10246-55
KPNA2 protein, human  0   *alpha Karyopherins.
Kap-alpha3 protein, Drosophila  0   *alpha Karyopherins *Drosophila Proteins DNA Helicases.
PKL-1c peptide  0   *Peptides *alpha Karyopherins. Bioorg Med Chem 2001 Dec;9(12):3215-23
Kpna6 protein, rat  0   *alpha Karyopherins.
KPNA1 protein, human  0   *alpha Karyopherins.
KPNA3 protein, human  0   *alpha Karyopherins. Cytogenet Cell Genet 1997;76(1-2):87-93
KPNA4 protein, human  0   *alpha Karyopherins DNA Helicases. Biochem Biophys Res Commun 1997 May 8;234(1):48-53
karyopherin alpha 2  0   *alpha Karyopherins RNA-Binding Proteins. Proc Natl Acad Sci U S A 1994 Jun 21;6156-60

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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