Definition: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
vaccines composed of recombinant DNA vectors encoding antigens
Other names Vaccines, Polynucleotide; Vaccines, Nucleic Acid; Vaccines, Naked DNA; DNA Vaccines, Recombinant; DNA Vaccines, Naked; Vaccines, Recombinant DNA; Recombinant DNA Vaccines; Polynucleotide Vaccines; Nucleic Acid Vaccines; Naked DNA Vaccines; DNA Vaccines