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Aldosterone Synthase

More information in Books or onNLM PubMed
Definition: A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.  do not confuse with other cytochrome P-450 CYP's    Other names Steroid 18 Hydroxylase; Cytochrome P 450c11AS; Cytochrome P 450 CYP11B2; P450c11AS; Cytochrome P450Aldo; Cytochrome P450 11B2; Cytochrome P-450c11AS; Cyctochrome P-450 c11AS; CYP 11B2; Aldosynthase; Aldosterone Synthase Cytochrome P-450; Steroid 18-Hydroxylase; Cytochrome P-450 CYP11B2; CYP11B2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LCI699  0   *Imidazoles *Pyridines Aldosterone Synthase/antagonists & inhibitors. Hypertension. 2010 Nov;56(5):831-8
4-((5-phenyl-1H-imidazol-1-yl)methyl)benzonitrile  0   *Imidazoles Aldosterone Synthase/antagonists & inhibitors. J Med Chem 2010 Feb 25;53(4):1712-25
18-Hydroxylase deficiency  0   *Hypoaldosteronism Aldosterone Synthase/deficiency.
5-((5-chloro-2,3-dihydro-1H-inden-1-ylidene)methyl)-1H-imidazole  0   *Imidazoles *Indenes Aldosterone Synthase/antagonists & inhibitors. J Med Chem 2005 Mar 24;48(6):1796-805
Cyp11b3 protein, rat  EC 1.14.15.4   *Aldosterone Synthase. J Biol Chem 1995 Jan 27;270(4):1643-9
corticosterone methyl oxidase I  EC 1.-   *Aldosterone Synthase. Endocr Rev 1981;2(4):495
corticosterone methyl oxidase II  EC 1.-   *Aldosterone Synthase. N Engl J Med 1980;303(3):117
corticosterone 18-monooxygenase  EC 1.14.15.4   *Aldosterone Synthase. J Clin Endocrinol Metab 46(2):236;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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