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Staurosporine
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Definition
: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Pharmacological Action
Enzyme Inhibitors
Substance
CAS Registry & name
Categories
Source
Drugs
*
10'-
(5''-
((methoxycarbonyl)amino)-
2'-
methyl)phenylaminocarbonylstaurosporine
0
Staurosporine/*analogs & derivatives.
J Asian Nat Prod Res. 2011 Aug;13(8):765-9
staurprimide
0
Staurosporine/*analogs & derivatives.
Cell Stem Cell 2009 May 8;4(5):416-26
7-
oxo-
8,9-
dihydroxy-
4'-
N-
demethylstaurosporine
0
Staurosporine/*analogs & derivatives.
J Nat Prod 2008 Jun;71(6):1046-8
7-
oxo-
3,8,9-
trihydroxystaurosporine
0
Staurosporine/*analogs & derivatives.
J Nat Prod 2008 Jun;71(6):1046-8
AFN941
0
Staurosporine/*analogs & derivatives.
Cancer Cell. 2007 Mar;11(3):209-11
selina-
4(14),7(11)-
diene-
8,9-
diol
0
Staurosporine/*analogs & derivatives.
J Antibiot (Tokyo). 2006 Jun;59(6):331-7
N-
carboxamido-
staurosporine
0
Staurosporine/*analogs & derivatives.
J Antibiot (Tokyo). 2006 Jun;59(6):331-7
ICP-
1 compound
0
Staurosporine/*analogs & derivatives.
Mol Cancer Ther 2002 Oct;1(12):1067-78
3-
hydroxy-
4'-
N-
demethylstaurosporine
0
Staurosporine/*analogs & derivatives.
J Nat Prod 2002 Mar;65(3):295-8
3'-
demethoxy-
3'-
hydroxy-
4'-
N-
demethylstaurosporine
0
Staurosporine/*analogs & derivatives.
J Nat Prod 2002 Mar;65(3):295-8
3-
hydroxy-
4'-
N-
methylstaurosporine
0
Staurosporine/*analogs & derivatives.
J Nat Prod 2002 Mar;65(3):295-8
5'-
hydroxystaurosporine
0
Staurosporine/*analogs & derivatives.
J Antibiot (Tokyo) 2000 Sep;53(9):895-902
4'-
N-
methyl-
5'-
hydroxystaurosporine
0
Staurosporine/*analogs & derivatives.
J Antibiot (Tokyo) 2000 Sep;53(9):895-902
PKC412
0
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
Anticancer Drug Des 2000 Feb;15(1):17-28
3'-
demethoxy-
3'-
hydroxystaurosporine-
O-
methyltransferase
EC 2.1.1.-
*Methyltransferases
Staurosporine.
J Antibiot (Tokyo) 1998 Jul;51(7):679-82
SCH 47112
0
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
Arch Dermatol Res 1997 Aug;289(9):540-6
CGP 44171A
0
Staurosporine/*analogs & derivatives.
Eur J Biochem 1995 Nov 15;234(1):317-22
3'-
demethoxy-
3'-
hydroxystaurosporine
0
Staurosporine/*analogs & derivatives.
J Antibiot (Tokyo) 1995 Apr;48(4):300-5
4'-
demethylamino-
4',5'-
dihydroxystaurosporine
155416-34-5 9,13-
Epoxy-
1H,9H-
diindolo(1,2,3-
gh:3',2',1'-
lm)pyrrolo(3,4-
j)(1,7)benzodiazonin-
1-
one, 2,3,10,11,12,13-
hexahydro-
11,12-
dihydroxy-
10-
methoxy-
9-
methyl-
, (9S-
(9alpha,10beta,11alpha,12alpha,13alpha))
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
J Antibiot (Tokyo) 1994 Mar;47(3):281-8
N-
ethoxycarbonyl-
7-
oxostaurosporine
143086-33-3
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
Cancer Lett 1992 Jun 15;64(2):177-83
7-
oxostaurosporine
141196-69-2 9,13-
Epoxy-
1H,9H-
diindolo(1,2,3-
gh:3',2',1'-
lm)pyrrolo(3,4-
j)(1,7)benzodiazonine-
1,3(2H)-
dione, 10,11,12,13-
tetrahydro-
10-
methoxy-
9-
methyl-
11-
(methylamino)-
, (9R-
(9alpha,10beta,11beta,13alpha))
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors
Streptomyces.
J Antibiot (Tokyo)1992 Feb;45(2):189-94
CGP 42700
121578-39-0 Benzamide, N-
(2,3,10,11,12,13-
hexahydro-
10-
methoxy-
9-
methyl-
1-
oxo-
2-
(phenylmethyl)-
9,13-
epoxy-
1H,9H-
diindolo(1,2,3-
gh:3',2',1'-
lm)pyrrolo(3,4-
j)(1,7)benzodiazonin-
11-
yl)-
N-
methyl-
, (9alpha,10beta,11beta,13alpha)
Staurosporine/*analogs & derivatives.
J Biol Chem 1992 Apr 5;267(10):6905-9
7-
O-
methyl-
UCN 01
125133-74-6
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
J Pharmacol Exp Ther 1990;255(3):1218
N,N-
dimethylstaurosporine
129623-30-9
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
Biochem Pharmacol 1990;40(2):343
4'-
demethylamino-
4'-
hydroxystaurosporine
126572-73-4 9,13-
Epoxy-
1H,9H-
diindolo(1,2,3-
gh:3',2',1'-
lm)pyrrolo(3,4-
j)(1,4)benzodiazonin-
1-
one, 2,3,10,11,12,13-
hexahydro-
11-
hydroxy-
10-
methoxy-
9-
methyl-
, (9R-
(9alpha,10beta,11beta,13alpha))
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
J Antibiot (Tokyo) 1990;43(2):163
4'-
N-
benzoylstaurosporine
120685-11-2 Benzamide, N-
(2,3,9,10,11,12-
hexahydro-
9-
methoxy-
8-
methyl-
1-
oxo-
8,12-
epoxy-
1H,8H-
2,7b,12a-
triazadibenzo(a,g)cyclonona(cde)trinden-
10-
yl)-
N-
methyl-
, (8alpha,9beta,10beta,12alpha)
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
Pharma Action
Antineoplastic Agents
;
Enzyme Inhibitors
Int J Cancer 1989;43(5):851
7-
hydroxystaurosporine
112953-11-4 8,12-
Epoxy-
1H,8H-
2,7b,12a-
triazadibenzo(a,g)cyclonona(cde)triinden-
1-
one, 2,3,9,10,11,12-
hexahydro-
3-
hydroxy-
9-
methoxy-
8-
methyl-
10-
(methylamino)
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors.
Pharma Action
Antineoplastic Agents
;
Protein Kinase Inhibitors
J Antibiot (Tokyo) 1987;40(12):1782