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Chaperonins

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Definition: A family of multisubunit protein complexes that form into large cylindrical structures which bind to and encapsulate non-native proteins. Chaperonins utilize the energy of ATP hydrolysis to enhance the efficiency of PROTEIN FOLDING reactions and thereby help proteins reach their functional conformation. The family of chaperonins is split into GROUP I CHAPERONINS, and GROUP II CHAPERONINS, with each group having its own repertoire of protein subunits and subcellular preferences.  general or unspecified; prefer specifics   
Examples Group I Chaperonins; Group II Chaperonins 		Other names Chaperonin Protein Complex; Chaperonin Family; Chaperonin Complexes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Bbs12 protein, mouse  0   *Chaperonins. Proc Natl Acad Sci U S A 2010 Jan 26;107(4):1488-93
BBS10 protein, mouse  0   *Chaperonins. Proc Natl Acad Sci U S A 2010 Jan 26;107(4):1488-93
AtVMA21b protein, Arabidopsis  0   *Chaperonins *Arabidopsis Proteins. Traffic. 2008 Sep;9(10):1618-28
AtVMA21a protein, Arabidopsis  0   *Chaperonins *Arabidopsis Proteins. Traffic. 2008 Sep;9(10):1618-28
CDC37 protein, human  0   *Cell Cycle Proteins *Chaperonins. Int J Oncol 2004 Sep;25(3):579-95
ATPAF2 protein, human  EC 3.6.3.14   *Proton-Translocating ATPases *Chaperonins.
AHA1 protein, S cerevisiae  0   *Chaperonins *Saccharomyces cerevisiae Proteins. J Biol Chem 2003 Apr 11;278(15):17228-35
PSMG2 protein, human  0   *Chaperonins Carcinoma, Hepatocellular. World J Gastroenterol 2001 Dec;7(6):821-5
Hsp16.3 protein, Mycobacterium tuberculosis  0   *Bacterial Proteins *Chaperonins. Biochem Biophys Res Commun 2001 Jun 22;284(4):942-7
TpCCTeta protein, Tetrahymena pyriformis  0   *Protozoan Proteins *Chaperonins. FEBS Lett 1996 Apr 1;383(3):277-83
GroESL protein, Bacteria  0   *Bacterial Proteins *Chaperonins. J Struct Biol 1995 Nov-Dec;115(3):258-66
BCL2-associated athanogene 1 protein  0   *DNA-Binding Proteins *Transcription Factors Membrane Proteins Cell Death Chaperonins. Cell 1995 Jan 27;80(2):279-84
htrE protein, E coli  0   *Bacterial Outer Membrane Proteins *Chaperonins *Escherichia coli Proteins. J Bacteriol 1993 Aug;175(16):5009-21
SymL protein, Bacteria  0   *Bacterial Proteins *Chaperonins Symbiosis. Biosystems 1984;17(2):127

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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