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Receptors, Transforming Growth Factor beta

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Definition: Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behavior of cells. Two types of transforming growth factor receptors have been recognized. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action.  DF: RECEPT TGF BETA    Other names Transforming Growth Factor beta Receptors; TGF-beta Receptors; Receptors, TGF-beta; TGF beta Receptors; TGF beta Receptor; Receptors, TGF beta; Receptor, TGF-beta; Transforming Growth Factor beta Receptor; TGF-beta Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride  0   *Imidazoles *Pyridines *Benzodioxoles Receptors, Transforming Growth Factor beta/antagonists & inhibitors. Mol Pharmacol. 2004 Mar;65(3):744-52
4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide  0   *Benzamides *Pyrazoles Receptors, Transforming Growth Factor beta/antagonists & inhibitors. J Med Chem 2006 Apr 6;49(7):2210-21
6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo(1,2-b)pyrazol-3-yl)-1H-benzoimidazole  0   *Benzimidazoles *Pyrazoles Receptors, Transforming Growth Factor beta/antagonists & inhibitors. J Med Chem 2006 Mar 23;49(6):2138-42
TGF-beta1 type III receptor (730-743), human  0   *Peptide Fragments *Receptors, Transforming Growth Factor beta. J Invest Dermatol 2005 Sep;125(3):450-5
TRIP-1 protein, Arabidopsis  0   *Arabidopsis Proteins Receptors, Transforming Growth Factor beta.
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide  0   *Benzamides *Dioxoles Receptors, Transforming Growth Factor beta/antagonists & inhibitors. Mol Pharmacol 2002 Jul;62(1):58-64
wit protein, Drosophila  0   *Receptors, Cell Surface *Drosophila Proteins Receptors, Transforming Growth Factor beta. Neuron 2002 Feb 14;33(4):529-43
trk-1 protein, Brugia pahangi  0   *Receptors, Transforming Growth Factor beta Helminth Proteins. Gene 1997 Oct 15;199(1-2):101-9
Habrec1 receptor, rat  0   *Receptors, Transforming Growth Factor beta.
EIF3I protein, human  171601-26-6   *Eukaryotic Initiation Factor-3 Receptors, Transforming Growth Factor beta. Nature 1995 Oct 12;377(6549):548-52
XTrR-I receptor  0   *Receptors, Transforming Growth Factor beta Protein-Serine-Threonine Kinases. Proc Natl Acad Sci U S A 1995 Jul 3;92(14):6474-8
TGF-beta type I receptor  EC 2.7.1.11   *Protein-Serine-Threonine Kinases *Receptors, Transforming Growth Factor beta. J Cell Biol 1994 Dec;127(6 Pt 2):2021-36
tkv protein, Drosophila  EC 2.7.1.-   *Receptors, Cell Surface *Protein-Serine-Threonine Kinases *Drosophila Proteins Receptors, Transforming Growth Factor beta. Cell 1994 Jul 29;78(2):225-37; Gene 1994 Oct 21;148(2):203-9
sax protein, Drosophila  0   *Drosophila Proteins *Receptors, Transforming Growth Factor beta Protein-Serine-Threonine Kinases. Science 1994 Mar 25;263(5154):1756-9
anti-Mullerian hormone receptor  0   *Receptors, Peptide *Receptors, Transforming Growth Factor beta Protein-Serine-Threonine Kinases. Endocrinology 1993 Dec;133(6):3007-13
daf-4 protein, C elegans  0   *Receptors, Transforming Growth Factor beta *Caenorhabditis elegans Proteins. Nature 1993 Oct 14;365(6447):644-9
transforming growth factor-beta type II receptor  EC 2.7.11.30   *Protein-Serine-Threonine Kinases *Receptors, Transforming Growth Factor beta Transforming Growth Factor beta. Biochem Biophys Res Commun 1993 Mar 31;191(3):790-5
betaglycan  145170-29-2   *Proteoglycans *Receptors, Transforming Growth Factor beta. Cell 1991;67(4):785

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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