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Trimetrexate

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Definition: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.     
Pharmacological Action Antifungal Agents; Antimetabolites, Antineoplastic; Folic Acid Antagonists 		Other names Trimetrexate Ipsen Brand; NSC328564; NSC249008; NSC 328564; NSC 249008; Monohydrate, Monoacetate Trimetrexate; JB 11; Hydrate, Trimetrexate; CI898; CI 898; Trimetrexate Monohydrate, Monoacetate; Trimetrexate Hydrate; NSC-328564; NSC-249008; JB-11; Ipsen Brand of Trimetrexate; CI-898; JB11
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
trimetrexate glucuronate  82952-64-5   *Glucuronates Drug Combinations Trimetrexate/*analogs & derivatives. JAMA 1988;260(2):224NEUTREXIN

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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