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Interleukin-4

More information in Books or onNLM PubMed
Definition: A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.  DF: IL 4 or IL4   
Pharmacological Action Adjuvants, Immunologic; Antineoplastic Agents; Antirheumatic Agents
See Also Histocompatibility Antigens Class II 		Other names B-Cell Growth Factor-I; Mast Cell Growth Factor-2; IL-4; Binetrakin; B-Cell Stimulatory Factor-1; Mast Cell Growth Factor 2; Interleukin 4; B Cell Stimulatory Factor 1; B Cell Stimulating Factor 1; B Cell Proliferating Factor; B Cell Growth Factor I; B Cell Growth Factor 1; MCGF-2; BSF-1; BCGF-1; B-Cell Stimulatory Factor 1; B-Cell Stimulating Factor-1; B-Cell Proliferating Factor; B-Cell Growth Factor-1; B Cell Stimulatory Factor-1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pitrakinra  0   *Interleukin-4 Interleukin-4/antagonists & inhibitors Interleukin-13/antagonists & inhibitors. Lancet 2007 Oct 20;370(9596):1422-31
IL4 protein, human  0   *Interleukin-4.
interleukin-4-Pseudomonas exotoxin  0   *Bacterial Toxins *Exotoxins *Interleukin-4. J Neurooncol 2003 Aug-Sep;64(1-2):125-37
deacetylravidomycin M  0   *Aminoglycosides Interleukin-4/antagonists & inhibitors. J Antibiot (Tokyo) 2001 Jul;54(7):554-61
interleukin-4 variant  0   *Interleukin-4. Blood 2001 Feb 1;97(3):752-8
interleukin 4 (38-37)-PE38KDEL  0   Interleukin-4 Immunotoxins. Nat Med 1999 Jul;5(7):817-22
interleukin 4 (1-129)-PE38KDEL  0   *Interleukin-4 Immunotoxins. Mat Med 1999 Jul;5(7):738-9
DAB(389)-interleukin 4  0   *Diphtheria Toxin *Interleukin-4 Recombinant Fusion Proteins Immunotoxins. J Allergy Clin Immunol 1995 Apr;95(4):893-900
diphtheria toxin-related-murine interleukin-4-fusion toxin  0   *Diphtheria Toxin *Interleukin-4 Recombinant Fusion Proteins. Protein Eng 1992 Apr;5(3):241-8
IL-4-PE40 protein, recombinant  0   *Exotoxins *Recombinant Fusion Proteins *Interleukin-4 Bacterial Proteins. Proc Natl Acad Sci USA 1989;86(11):4215

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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