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Histocompatibility Antigens Class I

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Definition: Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.  human & animal   
Examples HLA-A Antigens; HLA-B Antigens; HLA-C Antigens; HLA-G Antigens 		Other names Class I Antigens; I Antigens, Class; Antigens, Class I; Human Class I Antigens; Class I Major Histocompatibility Antigens; Class I Human Antigens; Class I Histocompatibility Antigens
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
M10.5 protein, mouse  0   *Histocompatibility Antigens Class I. PLoS Biol 2005 Aug;3(8):e257
Hfe protein, mouse  0   *Membrane Proteins *Histocompatibility Antigens Class I.
Mr1 protein, mouse  0   *Histocompatibility Antigens Class I Genes, MHC Class I.
Hlals protein, rat  0   *Histocompatibility Antigens Class I Genes, MHC Class I.
RAET1E protein, human  0   *Carrier Proteins *Membrane Proteins *Histocompatibility Antigens Class I. Biochem Biophys Res Commun. 2003 May 23;305(1):129-35; J Immunol 2004 Jul 15;173(2);1078-84
HFE protein, rat  0   *Membrane Proteins *Histocompatibility Antigens Class I. J Hepatol 2003 Sep;39(3):308-14
HCG8 protein, human  0   *HLA Antigens *Histocompatibility Antigens Class I.
transporter associated with antigen processing (TAP)  0   *ATP-Binding Cassette Transporters Histocompatibility Antigens Class I Antigen Presentation. World J Gastroenterol 2003 Aug;9(8):1853-5
UL16 binding protein 1, mouse  0   *Carrier Proteins *Histocompatibility Antigens Class I. J Immunol 2002 Oct 15;169(8):4079-83
MHC Ib Qa-2 antigen  0   *Histocompatibility Antigens Class I. Structure (Camb) 2001 Dec;9(12):1213-24
ULBP1 protein, human  0   *Intracellular Signaling Peptides and Proteins GPI-Linked Proteins Histocompatibility Antigens Class I. Immunity 2001 Feb;14(2):123-33
ULBP3 protein, human  0   GPI-Linked Proteins *Intercellular Signaling Peptides and Proteins Histocompatibility Antigens Class I. Immunity 2001 Feb;14(2):123-33
Gogo-H  0   *Histocompatibility Antigens Class I. Immunogenetics 2000 Jan;51(1):69-74
Mamu-I antigen  0   *Histocompatibility Antigens Class I. J Immunol 2000 Feb 1;164(3):1386-98
RDP 1258  0   *Oligopeptides Histocompatibility Antigens Class I. J Am Soc Nephrol 1999 Sep;10(9):1997-2005
decapeptide RDP 1257  0   *Peptide Fragments Histocompatibility Antigens Class I. Transplant Proc 1999 Feb-Mar;31(2B):1194
decapeptide B 2702  0   *Peptide Fragments Adjuvants, Immunologic Histocompatibility Antigens Class I HLA-B27 Antigen. Transplant Proc 1999 Feb-Mar;31(2B):1194
ZNRD1AS gene product, human  0   *Histocompatibility Antigens Class I. Immunogenetics 1998 May;47(6):491-6
Mamu-A 01 antigen  0   *Histocompatibility Antigens Class I Epitopes, T-Lymphocyte. Tissue Antigens 1997 Dec;50(6):657-61
HLA-hc protein, human  0   *Histocompatibility Antigens Class I Hemochromatosis Major Histocompatibility Complex. Immunogenetics 1997;45(5):336-40
HFE protein, human  0   *Membrane Proteins *Histocompatibility Antigens Class I. Biochem Biophys Res Commun 1997 Jan 3;230(1):35-9
Mamu-Mhc-BJ antigen  0   *Histocompatibility Antigens Class I. Immunogenetics 1996;45(1):80-1
Fc receptor, neonatal  0   *Receptors, Fc *Histocompatibility Antigens Class I Immunity, Maternally-Acquired. Mol Immunol 1996 Apr;33(6):521-30
MHC class I-related chain A  0   *Histocompatibility Antigens Class I. Immunogenetics 1996;44(1):80-1
MICB antigen  0   *Histocompatibility Antigens Class I. Immunogenetics 1996;43(4):230-3
AFP protein, human  0   *alpha-Fetoproteins Histocompatibility Antigens Class I. Genomics 1995 Sep 1;29(1):229-39
MR1 protein, human  0   *Histocompatibility Antigens Class I Genes, MHC Class I. Science 1995 Aug 4;269(5224):693-5
allotrap  151232-75-6   *Peptides Histocompatibility Antigens Class I. Transplantation 1995 Feb 27;59(4):455-60
Mamu-B 01 antigen, Macaca mulatta  0   *Histocompatibility Antigens Class I Epitopes. J Immunol 1995 Mar 1;154(5):2516-22
peptide 1, DA RT1(A)  0   *Peptides Histocompatibility Antigens Class I. Transplantation 1994 Dec 15;58(11):1236-40
Qdm protein, mouse  0   *Peptides Histocompatibility Antigens Class I Protein Sorting Signals. Cell 1994 Nov 18;79(4):649-58
HCG9 non-protein coding RNA, human  0   *RNA, Untranslated Histocompatibility Antigens Class I. Immunogenetics 1994;40(5):339-51
T22 antigen  130730-36-8   *Histocompatibility Antigens Class I. J Immunol 1994 Oct 1;153(7):3051-8
Mamu-A 02 antigen  0   *Histocompatibility Antigens Class I Epitopes, T-Lymphocyte. J Virol 1994 Oct;68(10):6690-6
histocompatibility antigen T10b  0   *Histocompatibility Antigens Class I. Cell 1994 Jan 14;76(1):29-37
D(kappa) (62-85) peptide  0   *Histocompatibility Antigens Class I. Endocrinology 1993 Sep;133(3):1247-51
H2-M3 antigen  0   *Histocompatibility Antigens Class I. J Immunol 1992 Dec 1;149(11):3605-11
PD7 antigen, Sus scrofa  137086-84-1   *Histocompatibility Antigens Class I. New Biol 1990;2(11):1024
C31 protein, mouse  0   *Histocompatibility Antigens Class I. J Exp Med 1990;172(6):1653
LA45 antigen  0   *Histocompatibility Antigens Class I. J Exp Med 1990;171(5):1431
HLA-AR antigen  0   *Histocompatibility Antigens Class I. J Immunol 1990;144(9):3619
histocompatibility antigen T10c  0   *Histocompatibility Antigens Class I. J Immunol 1990;144(6):2400
histocompatibility antigen 37  0   *Histocompatibility Antigens Class I. J Immunol 1990;144(6):2400
HLA-F antigens  0   *Histocompatibility Antigens Class I. J Exp Med 1990;171(1):1
feline leukocyte antigen  0   *Histocompatibility Antigens Class I. J Immunol 1989;142(10):3676
HLA-E antigen  0   *Histocompatibility Antigens Class I. J Immunol 1988;141(3):897
histocomptibility antigen H-42  0   *Histocompatibility Antigens Class I. Microbiol Immunol 1986;30(9):939
histocompatibility antigen H-8  0   *Histocompatibility Antigens Class I. Immunogenetics 1986;24(5):328
Tla antigens  0   *Histocompatibility Antigens Class I. Transplant Proc 1983;15(4):2033
histocompatibility antigen DLA  0   *Histocompatibility Antigens Class I. Immunogenetics 1984;19(2):95
Q surface antigens  0   *Histocompatibility Antigens Class I H-2 Antigens. J Supramol Struct 1981;16(2):167
pregnancy-specific antigen, sheep  0   *Pregnancy Proteins *Histocompatibility Antigens Class I. Biol Reprod 1980;22(3):675

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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