Meglutol (definition)

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Meglutol

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Definition: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.

Pharmacological Action Anticholesteremic Agents; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents

Other names 3-Hydroxy-3-methylglutaric Acid; beta Hydroxy beta Methylglutarate; Acid, 3-Hydroxy-3-methylpentanedioic; Acid, 3-Hydroxy-3-methylglutaric; 3 Hydroxy 3 methylpentanedioic Acid; 3 Hydroxy 3 methylglutaric Acid; beta-Hydroxy-beta-Methylglutarate; 3-Hydroxy-3-methylpentanedioic Acid

Substance	CAS Registry & name	Categories	Source
3-hydroxy-3-ethylglutaric acid	52939-72-7	Meglutol/*analogs & derivatives.	Biomed Mass Spectrom 1983;10(12):629
3-methylglutaric acid	626-51-7	Meglutol/*analogs & derivatives.	Clin Chem 1982;28(1):137
3-hydroxy-3-methylglutaric anhydride	34021-48-2 2H-Pyran-2,6(3H)-dione-4-14C, dihydro-4-hydroxy-4-methyl	Meglutol/*analogs & derivatives.	J Lipid Res 1981;22(1):184

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor

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