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Valinomycin

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Definition: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.     
Pharmacological Action Anti-Bacterial Agents; Ionophores
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cyclo((D-valyl-L-lactoyl-L-alanyl-D-hydroxyisovaleryl)2(D-valyl-L-lactoyl-L-valyl-D-hydroxyisovaleryl))  0   Valinomycin/*analogs & derivatives. Biopolymers 1997 Nov;42(6):651-8
dodeca-valinomycin  13507-80-7   Valinomycin/*analogs & derivatives. Bioorg Khim 1992 Jun;18(6):794-801
octa-valinomycin  14410-23-2 Valinomycin, 9-de(D-2-hydroxy-3-methylbutanoic acid)-10-de-D-valine-11-de(L-2-hydroxypropanoic acid)-12-de-L-valine  Valinomycin/*analogs & derivatives. Biopolymers 1992 Jul;32(7):757-64
hexadecaisoleucinomycin  65230-10-6 Cyclo(3-methyl-D-2-hydroxybutanoyl-D-isoleucyl-L-2-hydroxypropanoyl-L-isoleucyl-3-methyl-D-2-hydroxybutanoyl-D-isoleucyl-L-2-hydroxypropanoyl-L-isoleucyl-3-methyl-D-2-hydroxybutanoyl-D-isoleucyl-L-2-hydroxypropanoyl-L-isoleucyl-3-methyl-D-2-hydroxybutano  Valinomycin/*analogs & derivatives Ionophores. J Mol Graph 1989;7(2):82
cyclo(L-lactoyl-L-valyl-D-prolyl-D-valyl)3  65230-16-2   Valinomycin/*analogs & derivatives. J Gen Physiol 1981;77(4):387
cyclo(L-valyl-glycyl-glycyl-L-prolyl)3  41733-27-1 Cyclic(glycylglycyl-L-valyl-L-prolylglycylglycyl-L-valyl-L-prolylglycylglycyl-L-valyl-L-prolyl)  Valinomycin/*analogs & derivatives. Biochemistry 18(1):61;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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