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Tryptophan Oxygenase
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Definition
: A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.
See Also
Tryptophan Hydroxylase
Other names
Tryptophan Pyrrolase; Tryptophan 2,3 Dioxygenase; Pyrrolase, Tryptophan; Oxygenase, Tryptophan; Dioxygenase, TDO; 2,3-
Dioxygenase, Tryptophan; Tryptophan 2,3-
Dioxygenase; TDO Dioxygenase
Substance
CAS Registry & name
Categories
Source
Drugs
*
methyl-
thiohydantoin-
tryptophan
0
*Indoles
*Thiohydantoins
Tryptophan Oxygenase/antagonists & inhibitors.
Nat Med 2005 Mar;11(3):312-9
1-
methyl-
tryptophan
0
Tryptophan/*analogs & derivatives
Tryptophan Oxygenase/antagonists & inhibitors.
Biochim Biophys Acta 2000 Jan 3;1500(1):119-24
vermilion protein, Drosophila
EC 1.13.11.11
*Eye Proteins
*Tryptophan Oxygenase
*Drosophila Proteins.
Mol Cell Biol 1990 Apr;10(4):1423-31
diethylamine dinitric oxide adduct
92818-79-6
*Diethylamines
Tryptophan Oxygenase/antagonists & inhibitors.
Pharma Action
Nitric Oxide Donors
J Biol Chem 1994 May 20;269(20):14457-64
64C87
0
*Organic Chemicals
Tryptophan Oxygenase/antagonists & inhibitors.
Adv Exp Med Biol 1991;294:281
3-
(3-
benzofuranylalanine)
72071-49-9
*Benzofurans
Alanine/*analogs & derivatives
Tryptophan Oxygenase/antagonists & inhibitors.
Arch Biochem Biophys 1991;291(2):326
peptide-
tryptophan 2,3-
dioxygenase
EC 1.13.11.26
*Tryptophan Oxygenase.
Eur J Biochem 1986;156(2):317