encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 
ψ 
ψ 

Somatostatin

More information in Books or onNLM PubMed
Definition: A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.     
Pharmacological Action Hormones
See Also Receptors, Somatostatin
Examples Somatostatin-28 		Other names Somatotropin Release-Inhibiting Hormone; Somatostatin-14; Cyclic Somatostatin; Somatotropin Release Inhibiting Hormone; Somatotropin Release Inhibiting Factor; Somatostatin 14; Stilamin; Somatotropin Release-Inhibiting Factor; Somatostatin, Cyclic; Somatofalk; SRIH-14
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
gallium 68-DOTA-lanreotide  0   *Heterocyclic Compounds, 1-Ring *Peptides, Cyclic Somatostatin/*analogs & derivatives Gallium Radioisotopes Positron-Emission Tomography. Q J Nucl Med Mol Imaging. 2010 Feb;54(1):52-60
neuronostatin protein, rat  0   *Peptide Fragments *Somatostatin. J Biol Chem 2008 Nov 14;283(46):31949-59
BIM 23A760  0   Dopamine/*analogs & derivatives Somatostatin/*analogs & derivatives. Eur J Endocrinol 2005 Jul;153(1):135-41
CTAP octapeptide  0   *Peptide Fragments *Somatostatin.
BIM 23206  0   Somatostatin/*analogs & derivatives. J Clin Endocrinol Metab 2001 May;86(5):2161-9
BIM 23120  0   Somatostatin/*analogs & derivatives. J Clin Endocrinol Metab 2001 May;86(5):2161-9
BIM 23926  0   Somatostatin/*analogs & derivatives. Biochem Biophys Res Commun 2002 Oct 4;297(4):828-34
JF-10-81  0   *Camptothecin *Somatostatin. Cancer Lett 2007 Feb 8;246(1-2):157-66
pasireotide  0   Somatostatin/*analogs & derivatives. Methods Find Exp Clin Pharmacol 2005 Dec;27(10):711-38
PPSS3 protein, zebrafish  0   *Somatostatin *Zebrafish Proteins.
sst1 protein, zebrafish  0   *Somatostatin *Zebrafish Proteins.
sms-D70  0   Somatostatin/*analogs & derivatives. Ann N Y Acad Sci. 2004 Dec;1028():361-74
somatostatin, des-amino acid(1,2,5)-Glu(7)-Trp(8)-IAmp(9)-m-I-Tyr(11)-hhLys(12)  0   Somatostatin/*analogs & derivatives Receptors, Somatostatin/agonists. J Med Chem 2005 Jan 27;48(2):515-22
Woc4D  0   Somatostatin/*analogs & derivatives. Exp Eye Res 2002 May;74(5):553-9
thrittene protein, human  0   *Peptide Fragments *Somatostatin. Endocrinology 2002 Jul;143(7):2599-609
PTR-3205  0   Somatostatin/*analogs & derivatives. Bioorg Med Chem 2001 Dec;9(12):3255-64
technetium Tc 99m depreotide  0   *Organotechnetium Compounds Somatostatin/*analogs & derivatives. Clin Nucl Med 2001 Nov;26(11):910-2
AOD 9604  0   *Peptide Fragments *Somatostatin. Endocrinology 2001 Dec;142(12):5182-9
CMDTPA-Tyr(3)-octreotate  0   Glycine/*analogs & derivatives Somatostatin/*analogs & derivatives. Nucl Med Biol 2001 Apr;28(3):327-34
PTR 3173  0   Somatostatin/*analogs & derivatives. Endocrinology 2001 Jan;142(1):477-86
L 779976  0   *Amides *Indoles Somatostatin/agonists Receptors, Somatostatin/agonists. Science 1998 Oct 29;282(5389):737-40
L 817818  0   *Amides *Naphthalenes Somatostatin/agonists Receptors, Somatostatin/agonists. Science 1998 Oct 29;282(5389):737-40
somatostatin 14, Tyr(11)  0   Somatostatin/*analogs & derivatives. Biochem Biophys Res Commun 1999 Sep 24;263(2):276-80
BIM 23268  0   Somatostatin/*analogs & derivatives. J Clin Endocrinol Metab 1999 Sep;84(9):3268-76
Lan-7  0   Somatostatin/*analogs & derivatives. Clin Cancer Res 1997 Aug;3(8):1323-1330
NNC 26-9100  0   *Aminopyridines Thiourea/*analogs & derivatives Somatostatin/agonists. J Med Chem 1998 Nov 19;41(24):4693-705
L 054522  0   *Indoles *Benzimidazoles Somatostatin/agonists. Proc Natl Acad Sci U S A 1998 Sep 1;95(18):10836-41
BIM 23052  0   Somatostatin/*analogs & derivatives. Endocrinology 1998 Sep;139(9):3730-5
cyclo(N-benzylglycyl-phenylalanyl-tryptophyl-lysyl-threonyl-phenylalanyl)  0   Somatostatin/*analogs & derivatives. J Med Chem 1998 Jul 16;41(15):2679-85
cyclo(beta-methyl-N-benzylglycyl-phenylalanyl-tryptophyl-lysyl-threonyl-phenylalanyl)  0   Somatostatin/*analogs & derivatives. J Med Chem 1998 Jul 16;41(15):2679-85
DC 32-87  0   Somatostatin/*analogs & derivatives. Gastroenterology 1998 Jun;114(6):1125-32
CH 288  0   Somatostatin/*analogs & derivatives Iodine Radioisotopes Ligands. Eur J Pharmacol 1997 Oct 22;337(2-3):333-6
CH 275  0   Somatostatin/*analogs & derivatives. Eur J Pharmacol 1997 Oct 22;337(2-3):333-6
TT2-32  0   Somatostatin/*analogs & derivatives. Tumour Biol 1995;16(4):261-7
prosomatostatin (29-92)  0   *Protein Precursors *Somatostatin. Biochem J 1994 Oct 1;303( Pt 1):263-8
somatostatin 26  0   *Somatostatin. Regul Pept 1993 Aug 13;47(1):33-39
ASS 52  150747-53-8 L-Cysteinamide, N--((1-mercaptocyclohexyl)acetyl)-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxyethyl)-, cyclic (1-5)-disulfide  Somatostatin/*analogs & derivatives. Neuropeptides 1993 Jul;2591):57-60
ASS 51  150747-52-7 L-Cysteinamide, N- ((1-mercaptocyclohexyl)acetyl)-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)-1-methylethyl)-, cyclic (1-5)-disulfide  Somatostatin/*analogs & derivatives. Neuropeptides 1993 Jul;25(1):57-60
pentetreotide  138661-02-6 L-Cysteinamide, N-(2-((2-(bis(carboxymethyl)amino)ethyl)(carboxymethyl)amino)ethyl)-N-(carboxymethyl)glycyl-D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (3-8)-disulfide, (R-,(R*,  Somatostatin/*analogs & derivatives Indium Radioisotopes. Br J Cancer 1993 Jun;67(6):1437-9OCTREOSCAN
somatostatin, Pro(2)-Met(13)  145038-23-9   Somatostatin/*analogs & derivatives. Biochem Biophys Res Commun 1992 Oct 15;188(1):477-82
BIM 23034  111857-95-5 D-Alaninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-3-(2-naphthalenyl)-, cyclic (2-7)-disulfide  *Oligopeptides Somatostatin/*analogs & derivatives. Peptides 1991 Jul-Aug;12(4):839-43
somatostatin 34  132894-19-0 Somatostatin-34  *Somatostatin. Gen Comp Endocrinol 1991;82(1):93
BIM 23003  135048-17-8 Somatostatin (sheep), 1-de-L-alanine-2-deglycine-3-(N-acetyl-L-cysteine)-6-(4-chloro-L-phenylalanine)-8-D-tryptophan  *Peptide Fragments Somatostatin/*analogs & derivatives. Neuroscience 1990;39(3):761
somatostatin, azidonitrobenzoyl-Lys(9)-iodo-Tyr(11)  130772-41-7   Somatostatin/*analogs & derivatives. J Biol Chem 1990;265(29):17995
somatostatin, azidonitrobenzoyl-Lys(4)-iodo-Tyr(11)  130772-40-6   Somatostatin/*analogs & derivatives. J Biol Chem 1990;265(29):17995
RC 161  103237-51-0   Somatostatin/*analogs & derivatives. Proc Natl Acad Sci USA 1990;87(17):6762
somatostatin (7-10), desamino-Trp  125757-85-9   *Peptide Fragments Somatostatin/*analogs & derivatives. Acta Physiol Hung 1989;73(2-3):199
lanreotide  118992-92-0 L-Threoninamide, 3-(1-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide  *Peptides, Cyclic Somatostatin/*analogs & derivatives Acromegaly.
Pharma Action Antineoplastic Agents 		Prostaglandins 1989;37(3):345SOMATULINE DEPOT
antrin  112173-60-1   *Peptide Fragments *Somatostatin. J Clin Invest 1989;83(2):367
angiopeptin  113294-82-9   *Oligopeptides Somatostatin/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Cardiovascular Agents 		Biochem Biophys Res Commun 1988;153(1):81
somatostatin RC 102  99685-66-2   Somatostatin/*analogs & derivatives. Peptides 1987;8(5):951
phenylalanyl-cyclo(cysteinyl-tyrosyltryptophyl-lysyl-threonyl-penicillamine)threoninamide  96384-03-1   Somatostatin/*analogs & derivatives. J Pharmacol Exp Ther 1987;240(3):772
vapreotide  0   Somatostatin/*analogs & derivatives.
Pharma Action Analgesics ; Antineoplastic Agents 		Proc Natl Acad Sci USA 1987;84(4):1112
prosomatostatin cryptic peptide  105655-57-0   *Peptide Fragments *Protein Precursors *Somatostatin. Cell Tissue Res 1986;246(1):197
somatostatin, seleno-Cys(3,14)-Trp(8)  77201-60-6   Somatostatin/*analogs & derivatives. Biomed Biochim Acta 1986;45(5):611
phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide  103429-31-8   Somatostatin/*analogs & derivatives. Life Sci 1986;38(24):2221
Phe-Cys-Phe-Trp-Lys-Thr-Pen-Thr-NH2  96384-04-2   Somatostatin/*analogs & derivatives. Proc West Pharmacol Soc 1985;28:165
somatostatin, Ala(5)-Orn(9)  102502-51-2   Somatostatin/*analogs & derivatives. Bioorg Khim 1985;11(8):1026
somatostatin, N-Ac-des-Ala(1)-des-Gly(2)-4-Cl-Phe(6)-Trp(8)  0   Somatostatin/*analogs & derivatives. Peptides (Fayetteville) 1985;6(6):1245
D,D-carbasomatostatin  59983-96-9   Somatostatin/*analogs & derivatives. Nippon Yakurigaku Zasshi 1985;86(3):189
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy