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Sialyltransferases

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Definition: A group of enzymes with the general formula CMP-N-acetylneuraminate:acceptor N-acetylneuraminyl transferase. They catalyze the transfer of N-acetylneuraminic acid from CMP-N-acetylneuraminic acid to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid. EC 2.4.99.-.      Other names Glycoprotein Sialyltransferases; Sialyltransferases, Glycoprotein; Sialyltransferase, Glycoprotein; Glycoprotein Sialyltransferase; Ectosialyltransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
polysialyltransferase-1, human  EC 2.4.99.-   *Sialyltransferases. Brain Pathol. 2010 Mar;20(2):431-40
AL-10 compound  0   Lithocholic Acid/*analogs & derivatives Sialyltransferases/antagonists & inhibitors. J Cell Physiol. 2010 May;223(2):492-9
beta-galactoside alpha-2,6-sialyltransferase, human  EC 2.4.99.1   *Sialyltransferases Nerve Tissue Proteins. Glycoconj J 2010 Jan;27(1):99-114
ST8SiaII protein, mouse  EC 2.4.99.-   *Sialyltransferases. J Biol Chem 2008 Jan 18;283(3):1463-71
ST8SiaIV protein, mouse  EC 2.4.99.8   *Sialyltransferases. J Biochem 1995 Sep;118(3):658-64
CMP-acetylneuraminyl N-acetylgalactosaminyl-IgA1 alpha2,6-sialyltransferase, human  EC 2.4.99.-   *Sialyltransferases. J Mol Biol 2007 May 25;369(1):69-78
ST8Sia IV protein, swine  EC 3.4.99.-   *Sialyltransferases. Nutr Neurosci 2006 Jun-Aug;9(3-4):147-54
ST8SIA4 protein, human  EC 3.4.99.-   *Sialyltransferases. J Biol Chem 2000 Oct 20;275(42):32861-70
rtST6GalNAc, rainbow trout  EC 2.4.99.-   *Sialyltransferases. J Biochem (Tokyo). 2004 Aug;136(2):189-98
ST6GALNAC4 protein, human  EC 2.4.99.7   *Sialyltransferases.
GalNAc sialyltransferase VI  EC 2.4.99.-   *Sialyltransferases. J Biol Chem 2003 Jun 20;278(25):22787-94
O-acetyl disialoganglioside synthase, rat  EC 2.4.99.-   *Sialyltransferases. Biochem Biophys Res Commun 2003 Apr 11;303(3):954-61
alpha2,8-sialyltransferase VI  EC 3.4.99.-   *Sialyltransferases. J Biol Chem 2002 Jul 5;277(27):24030-8
NeuS protein, E coli  EC 2.4.-   *Sialyltransferases *Escherichia coli Proteins. J Biol Chem 1999 Dec 3;274(49):35139-46
brain-specific GD1alpha synthase, ST6GalNAc V  EC 2.4.99.-   *Sialyltransferases. J Biol Chem 1999 Oct 22;274(43):30557-62
Siat7d protein, mouse  EC 2.4.99.7   *Sialyltransferases. J Biol Chem 1999 Apr 23;274(17):11958-67
Lst protein, Haemophilus ducreyi  EC 2.4.99.-   *Bacterial Proteins *Sialyltransferases. J Biol Chem 1999 Feb 12;274(7):4106-14
ST8SIA5 protein, human  EC 3.4.99.-   *Sialyltransferases. Biochem Biophys Res Commun 1997 Jun 18;235(2):327-30
CMP-NeuAc-(NeuAc-alpha-2-8)n sialyltransferase  EC 2.4.99.-   *Sialyltransferases. Glycoconj J 1995 Dec;12(6):829-37
neolactotetraosylceramide alpha-2,3-sialyltransferase  EC 2.4.99.10   *Sialyltransferases. Biochemistry 1996 Apr 23;35(16):5166-74
Neu5Ac N-acetylgalactosamine 2,6-sialyltransferase  EC 2.4.99.-   *Sialyltransferases. J Biol Chem 1996 Mar 29;271(13):7450-9
Sia(alpha2,3)Gal(beta1,4)GlcNAc alpha-2,8-sialyltransferase  EC 2.4.99.-   *Sialyltransferases. J Biol Chem 1995 Jun 16;270(24):14628-33
ST6GAL1 protein, human  EC 2.4.99.1   *Antigens, CD *Sialyltransferases. J Cell Biol 1992 Jan;116(2):423-35
alpha2-8-KDN-transferase  EC 2.4.99.-   *Sialyltransferases. Glycoconj J 1994 Oct;11(5):493-9
galactosyl-1-3-N-acetylgalactosaminyl-specific 2,6-sialyltransferase  EC 2.4.99.-   *Sialyltransferases. J Biol Chem 1994 Jul 22;269(29):19048-53
(Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase  EC 2.4.99.7   *Sialyltransferases. Glycoconj J 1989;6(1):115-27
KI 8110  80681-73-8 Uridine, 5'-O-(N-acetyl-4,7,8,9-tetra-O-acetyl-1-methyl-alpha-neuraminosyl)-5-fluoro-2',3'-O-(1-methylethylidene)  *Glycosides Uridine/*analogs & derivatives Sialyltransferases/antagonists & inhibitors. Cancer Res 1986;46(2):858
CMP-N-acetylneuraminate-poly-alpha-2,8-sialosyl sialyltransferase  EC 2.4.99.-   *Sialyltransferases. J Biol Chem 1985;260(23):12695
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase  EC 2.4.99.8   *Sialyltransferases. J Neurosci Res 1984;12(2-3):257
CMP-N-acetylneuraminate-alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase  EC 2.4.99.3   *Sialyltransferases. J Biol Chem 1983;258(12):7430
beta-galactosyl(1-3)N-acetylglucosaminide alpha(2-3)-sialyltransferase  EC 2.4.99.-   *Sialyltransferases. J Biol Chem 1982;257(8):4034
beta-galactoside alpha-2,3-sialyltransferase  EC 2.4.99.4   *Sialyltransferases. Eur J Biochem 1982;121(3):567
glycolipid sialyltransferase  EC 2.4.99.-   *Sialyltransferases. Biochim Biophys Acta 1981;678(2):313
beta-D-galactoside alpha 2-6-sialyltransferase  EC 2.4.99.1   *Sialyltransferases Antigens, CD. Can J Biochem 1972;50(9):1024; Pediatr Res 1981;15(5):839
N-acetyllactosaminide alpha-2,3-sialyltransferase  EC 2.4.99.6   *Sialyltransferases. J Biol Chem 1981;256(7):3159
haematoside synthetase  EC 2.4.99.9   *Sialyltransferases. Biochem Biophys Res Commun 59(1):292;1974; Biochem J 168(3):326;1977
CMPsialic acid-apolipoprotein glycosyltransferase  EC 2.4.99.-   *Sialyltransferases. Arch Biochem Biophys 169(1):269;1975
CMP-N-acetylneuraminic acid-monosialoganglioside sialyltransferase  EC 2.4.99.2   *Sialyltransferases. Biochim Biophys Acta 306(2):298;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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