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Receptor, Insulin

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Definition: A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.     
See Also Donohue Syndrome 		Other names Insulin Receptor beta Subunit; Insulin Receptor alpha Subunit; Insulin Receptor Protein-Tyrosine Kinase; Insulin Receptor; Insulin Receptors; Insulin Receptor Protein Tyrosine Kinase; Receptors, Insulin; Insulin-Dependent Tyrosine Protein Kinase; Insulin Receptor beta Chain; Insulin Receptor alpha Chain
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AGL 2263  0   *Benzoxazoles Chalcone/*analogs & derivatives Receptor, Insulin/antagonists & inhibitors. Biochem Biophys Res Commun 2009 Jun 12;383(4):503-8
S961 peptide  0   *Peptides Receptor, Insulin/antagonists & inhibitors. Biochem Biophys Res Commun 2008 Nov 14;376(2):380-3
S661 peptide  0   *Peptides Receptor, Insulin/antagonists & inhibitors. Biochem Biophys Res Commun 2008 Nov 14;376(2):380-3
IRS3P protein, human  0   *Insulin Receptor Substrate Proteins Receptor, Insulin.
Irs3 protein, rat  0   *Insulin Receptor Substrate Proteins Receptor, Insulin.
daf-28 protein, C. elegans  0   *Receptor, Insulin *Caenorhabditis elegans Proteins. Genes Dev 2003 Apr 1;17(7):844-58
INSR protein, human  EC 2.7.10.1   *Receptor, Insulin *Antigens, CD. J Cell Biochem 2001;82(4):610-8
2,5-dihydroxy-6-(1-methylindol-3-yl)-3-phenyl-1,4-benzoquinone  0   *Benzoquinones Receptor, Insulin/antagonists & inhibitors. J Med Chem 2000 Sep 21;43(19):3487-94
insulin receptor tyrosine kinase  EC 2.7.1.-   *Protein-Tyrosine Kinases Receptor, Insulin. Diabetes 2000 Mar;49(3):325-31
AP3S1 protein, human  0   *Nerve Tissue Proteins *Adaptor Protein Complex 3 *Adaptor Protein Complex sigma Subunits Receptor, Insulin. Cytogenet Cell Genet 1996;73(3):214-7; Gene. 1999 Nov 29;240(2):297-305.; J Biol Chem 1998 Nov 6;273(45):29942-9
Irs3 protein, mouse  0   *Insulin Receptor Substrate Proteins Receptor, Insulin. Endocrinology 1997 Nov;138(11):4931-40
DAF-2 protein, C elegans  0   *Receptor, Insulin *Caenorhabditis elegans Proteins. Science 1997 Aug 15;277(5328):942-6
insulin receptor (1293-1307)  0   *Peptide Fragments *Receptor, Insulin. J Biol Chem 1996 Dec 6;271(49):31619-26
GRB10 protein, human  0   *GRB10 Adaptor Protein Receptor, Insulin. Proc Natl Acad Sci U S A 1995 Oct 24;92(22):10287-91
insulin receptor peptide (1135-1156)  0   *Peptide Fragments *Receptor, Insulin Receptor, Insulin. Biochem J 1993 Aug 15;294(Pt 1):19-24
insulin receptor serine kinase  EC 2.7.1.11   *Receptor, Insulin *Protein-Serine-Threonine Kinases. Mol Cell Biochem 1993 Apr 21;121(2):167-74
insulin receptor-related receptor  0   *Receptor, Insulin. Cytogenet Cell Genet 1990;54(1-2):80
insulin-stimulated phosphoprotein pp105  0   *Phosphoproteins Nerve Tissue Proteins Receptor, Insulin. J Biol Chem 1987;262(8):3436
insulin proreceptor  0   *Protein Precursors *Receptor, Insulin. Biochem J 1986;239(3):679
taurine receptor  0   *Receptors, Neurotransmitter Receptor, Insulin. Adv Biochem Psychopharmacol 1981;29:127
aglycoinsulin receptor  0   *Receptor, Insulin. J Biol Chem 1981;256(10):4707

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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