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Receptors, Estrogen

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Definition: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.  coord IM with specific estrogen (IM); DF: RECEPT ESTROGEN   
Examples Estrogen Receptor alpha; Estrogen Receptor beta; Receptors, Estradiol 		Other names Estrogen Receptors; Nuclear Receptor, Estrogen; Receptors, Estrogen, Type II; Receptors, Estrogen, Type I; Receptor, Estrogen Nuclear; Estrogen Receptors Type II; Estrogen Receptors Type I; Estrogen Receptor Type II; Estrogen Receptor Type I; Estrogen Nuclear Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(4-hydroxyphenyl)-3-phenylpent-2-enoic acid (4-(2-dimethylaminoethoxy)phenyl)amide  0   *Acrylamides Ligands Receptors, Estrogen/antagonists & inhibitors. Endocrinology 2010 Oct;151(10):4926-37
N-(3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-ylidene)-5H-dibenzo(a,d)(7)annulen-5-amine  0   *Thiazolidines Receptors, Estrogen/antagonists & inhibitors. Mol Cancer Ther 2009 Mar;8(3):672-81
estrogen receptor 2a, zebrafish  0   *Receptors, Estrogen *Zebrafish Proteins. Dev Dyn 2006 Nov;235(11):3071-9
m-bis(hydroxyphenyl)carborane  0   *Boron Compounds *Phenols Receptors, Estrogen/agonists. Bioorg Med Chem Lett 2006 Aug 1;16(15):3943-6
Esrrg protein, rat  0   *Receptors, Estrogen. Gene 2004 Oct 13;340(2):275-82
dfna5 protein, zebrafish  0   *Receptors, Estrogen *Zebrafish Proteins Deafness.
Dfna5h protein, mouse  0   *Receptors, Estrogen Deafness.
ESRRB protein, human  0   *Receptors, Estrogen.
ESRRG protein, human  0   *Receptors, Estrogen.
Esrrg protein, mouse  0   *Receptors, Estrogen.
estrogen receptor activator protein, rat  0   *Proteins Receptors, Estrogen.
Safb protein, rat  0   *Receptors, Estrogen *Nuclear Matrix-Associated Proteins *Matrix Attachment Region Binding Proteins.
SAFB2 protein, human  0   *Receptors, Estrogen *Nuclear Matrix-Associated Proteins *Matrix Attachment Region Binding Proteins.
ERB 041  0   *Oxazoles Receptors, Estrogen/agonists. Endocrinology 2003 Oct;144(10):4241-9
estrogen receptor deltaE7  0   *Receptors, Estrogen. Endocrinology. 2003 Jul;144(7):2967-76
ERR protein, Drosophila  0   *Receptors, Estrogen *Drosophila Proteins. Biochemistry 2003 Jun 3;42(21):6427-35
7-thiophenylestradiol  0   Estradiol/*analogs & derivatives Receptors, Estrogen/agonists. Endocrinology 2002 Oct;143(10):3785-95
ER-X protein, mouse  0   *Receptors, Estrogen. J Neurosci 2002 Oct 1;22(19):8391-401
estrogen receptor gamma  0   *Receptors, Estrogen. Endocr Regul 2000 Dec;34(4):203-18
13beta-methyl 19-nor-steroid  0   *Steroids Receptors, Estrogen. Steroids 2000 Oct - Nov;65(10 -11):763-71
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole  0   *Phenols *Pyrazoles Receptors, Estrogen/agonists. J Med Chem 2000 Dec 28;43(26):4934-47
NNC 45-0095  0   *Indolizines *Pyrroles Receptors, Estrogen/agonists. Bioorg Med Chem Lett 2000 Feb 21;10(4):399-402
TERP-1  0   *Receptors, Estrogen. Mol Endocrinol 1999 Feb;13(2):320-91
DFNA5 protein, human  0   *Receptors, Estrogen Deafness. Eur J Biochem 1998 Feb 15;252(1):169-77
GPER protein, human  0   *Receptors, Estrogen *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun 1997 Nov 26;240(3):737-41; Genomics 1997 Nov 1;45(3):607-17
SAFB protein, human  0   *Receptors, Estrogen *Nuclear Matrix-Associated Proteins *Matrix Attachment Region Binding Proteins. J Cell Biochem 1997 Nov 1;67(2):275-86
levormeloxifene  78994-23-7   *Pyrrolidines Receptors, Estrogen/agonists. J Clin Invest 1997 Aug 15;100(4):821-8
estrogen receptor-related receptor beta  0   *Receptors, Estrogen. Nature 1997 Aug 21;388(6644):778-82
estrogen binding site, type II  0   *Receptors, Estrogen. Am J Respir Cell Mol Biol 1997 Jul;17(1):51-9
Esrrb protein, mouse  0   *Receptors, Estrogen. Genomics 1998 Jun 15;50(3):382-4; J Biol Chem 1996 Apr 26;271(17):9879-82; J Biol Chem 1999 Aug 6;274(32):22618-26
ERRalpha estrogen-related receptor  0   *Receptors, Estrogen. J Biol Chem 1996 Mar 8;271(10):5795-804
nuclear receptor interacting protein 1  0   *Nuclear Proteins *Adaptor Proteins, Signal Transducing Receptors, Estrogen Repressor Proteins. EMBO J 1995 Aug 1;14(15):3741-51
3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid  155701-61-4   *Cinnamates *Stilbenes Receptors, Estrogen/antagonists & inhibitors. J Med Chem 1994 May 27;37(11):1550-2
ERD5 protein, human  0   *Receptors, Estrogen Antigens Breast Neoplasms Tumor Markers, Biological. Eur J Gynaecol Oncol 1989;10(2):141
estrophilin platinum complex  0   *Carrier Proteins *Organoplatinum Compounds Receptors, Estrogen. Virchows Arch [B[ 1987;53(4):198
estriol receptor  0   *Receptors, Estrogen Estriol. J Steroid Biochem 1984;21(2):163
2-(4-methoxyphenyl)-4'-(2-(1-pyrrolidinyl)ethoxy)deoxybenzoin  87198-64-9   Nitromifene/*analogs & derivatives Receptors, Estrogen/drug effects. J Med Chem 1983;26(12):1701; Life Sci 1983;33(11):1051
estrone receptor  0   *Receptors, Estrogen Estrone. Hormone Res 1983;17(3):168
5S-CA  0   *Blood Proteins Receptors, Estrogen. Proc Nat Acad Sci 75(6):2664;1978
4-hydroxytamoxifen  68392-35-8 phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,  Tamoxifen/*analogs & derivatives Receptors, Estrogen/agonists.
Pharma Action Estrogen Antagonists 		Adv Exp Med Biol 117:133;1979; Biochem Biophys Res Commun 1979;91(3):812; J Endocrinol 76(2):363;1978; J Endocrinol 78(1):71;1978; J Steroid Biochem 1979;11(1A):285
estrophilin  0   *Carrier Proteins *Receptors, Estrogen Fungal Proteins. Arch Surg 112(2):183;1977; Clin Chem 24(10):1848;1978; Phys Chem Basic Biol Info Trans W3 IN133R:211;1974; Vitam Horm Adv Res Appl 32:89;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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