encyclopedia of medical concepts
ψ 

Spermidine Synthase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthiopropylamine)sulfonium adenosine to putrescine in the biosynthesis of spermidine. The enzyme has a molecular weight of approximately 73,000 kDa and is composed of two subunits of equal size.  do not confuse with SPERMINE SYNTHASE    Other names Spermidine Synthetase; Propylamine Transferase; Aminopropyltransferase; Transferase, Propylamine; Synthetase, Spermidine; Synthase, Spermidine; Aminopropyltransferase, Putrescine; Putrescine Aminopropyltransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SpdA protein, Aspergillus nidulans  EC 2.5.1.6   *Spermidine Synthase. Mol Microbiol 2002 Nov;46(3):801-12
SPDS2 protein, Arabidopsis  EC 2.5.1.16   *Spermidine Synthase *Arabidopsis Proteins. Plant Cell 2002 Oct;14(10):2539-51
SPDS1 protein, Arabidopsis  EC 2.5.1.16   *Spermidine Synthase *Arabidopsis Proteins. Plant Cell 2002 Oct;14(10):2539-51
adenosylspermidine  0   Adenosine/*analogs & derivatives Spermidine/*analogs & derivatives Spermidine Synthase/antagonists & inhibitors. J Med Chem 1995 Jul 7;38(14):2714-27
bis(cyclohexylammonium)sulfate  17911-61-4   *Cyclohexylamines Spermidine Synthase/antagonists & inhibitors. Cell Biol Int Rep 1992 Apr;16(4):349-58
4-methylcyclohexylamine  6321-23-9   *Cyclohexylamines Spermidine Synthase/antagonists & inhibitors. Chem Pharm Bull 1989;36(8):3220
3-methylthiopropylamine  4104-45-4   *Propylamines Spermidine Synthase/antagonists & inhibitors. Anticancer Res 1987;7(6):1213
methylglyoxal bis(cyclohexylamidinohydrazone)  114319-00-5   Mitoguazone/*analogs & derivatives Spermidine Synthase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem Pharmacol 1988;37(2):364
juglorin  109521-81-5 2,6-Epoxy-2H-naphth(2,3-d)oxocin-2-acetic acid, 4-ethyl-1,4,5,6,8,11-hexahydro-7-hydroxy-5-methyl-8,11-dioxo-, (2alpha,4alpha,5alpha,6alpha)  *Naphthoquinones Spermidine Synthase/antagonists & inhibitors. J Antibiot (Tokyo) 1987;40(5):717
N-chlorosulfonyl dicyclohexylamine  99700-74-0   *Cyclohexylamines Spermidine Synthase/antagonists & inhibitors. Biochem Biophys Res Commun 1986;141(2):718
1-aminooxy-3-aminopropane  98532-00-4 1-Propanamine, 3-(aminooxy)  *Propylamines Ornithine Decarboxylase/antagonists & inhibitors Spermidine Synthase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem Biophys Res Commun 1985;130(2):596
S-adenosyl-3-thiopropylamine  53186-57-5   S-Adenosylhomocysteine/*analogs & derivatives Spermidine Synthase/antagonists & inhibitors. Biochem J 153(3):567;1976

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy