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Pirenzepine

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Definition: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.     
Pharmacological Action Anti-Ulcer Agents; Muscarinic Antagonists 		Other names Pirenzepin ratiopharm; Piren basan; LS519; LS 519; Dihydrochloride, Pirenzepine; ratiopharm Brand of Pirenzepine Dihydrochloride; pirenzepin von ct; ct-Arzneimittel Brand of Pirenzepine Dihydrochlori; Ulgescum; Sagitta Brand of Pirenzepine Dihydrochloride; Ulcoprotect; Pyrenzepine; Pirenzepine Dihydrochloride; Pirenzepin-ratiopharm; Pirenzepin; Piren-basan; LS-519; L-S 519; Gastrozepin; Gastrotsepin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4'-N-demethylolanzapine  0   Pirenzepine/*analogs & derivatives. Ther Drug Monit 2002 Aug;24(4):518-26
desmethylolanzapine  0   Pirenzepine/*analogs & derivatives. J Chromatogr B Biomed Sci Appl 2001 Jan 5;750(1):137-46
Bodipy-pirenzepine  0   *Boron Compounds Pirenzepine/*analogs & derivatives Fluorescent Dyes. J Neurosci 1994 Jul;14(7):4147-58
AQ-RA 721  139051-89-1 5H-Dibenz(b,e)azepine-11-carboxamide, N-1-azabicyclo(2.2.2)oct-3-yl-6,11-dihydro-6-oxo  Pirenzepine/*analogs & derivatives. Agents Actions Suppl 1991;34:117-30
guanylpirenzepine  122858-76-8   Pirenzepine/*analogs & derivatives. J Recept Res 1990;10(1-2):81
AFDX 384  118290-27-0 11H-Pyrido(2,3-b)(1,4)benzodiazepine-11-carboxamide, N-(2-(2-((dipropylamino)methyl)-1-piperidinyl)ethyl)-5,6-dihydro-6-oxo-, monomethanesulfonate  Pirenzepine/*analogs & derivatives.
Pharma Action Parasympatholytics 		Biochem Pharmacol 1990;40(7):1674
N-methylpyrenzepine  107425-93-4   Pirenzepine/*analogs & derivatives. Am J Med Sci 1988;296(6):399
LS 75  885-70-1   Pirenzepine/*analogs & derivatives. Ther Drug Monit 1987;9(2):236
LS 822  63257-31-8   Pirenzepine/*analogs & derivatives. Ther Drug Monit 1987;9(2):236
otenzepad  102394-31-0 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 11-((2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro  Pirenzepine/*analogs & derivatives.
Pharma Action Anti-Arrhythmia Agents ; Parasympatholytics 		Life Sci 1986;38(18):1653
telenzepine  80880-90-6   Pirenzepine/*analogs & derivatives.
Pharma Action Parasympatholytics 		Eur J Pharmacol 1985;112(2):211

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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