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Phosphofructokinase-1

More information in Books or onNLM PubMed
Definition: An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.  GEN or unspecified; prefer specifics   
See Also Glycogen Storage Disease Type VII; Phosphofructokinase-2
Examples Phosphofructokinase-1, Liver Type; Phosphofructokinase-1, Muscle Type; Phosphofructokinase-1, Type C 		Other names 6-Phosphofructokinase; Phosphofructokinase 1; 6 Phosphofructokinase; Fructose-6-phosphate 1-Phosphotransferase; Fructose-6-P 1-Kinase; 6-Phosphofructo-1-kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1,1-hydroxyoctanodiphosphonate  53019-19-5   *Diphosphonates Phosphofructokinase-1/antagonists & inhibitors. Rev Latinoam Microbiol 1992 Oct-Dec;34(4):275-80
1-phosphofructokinase  EC 2.7.1.56   *Phosphofructokinase-1. J Bacteriol 1991;173(10):3117
Ptms protein, rat  0   *Proteins Phosphofructokinase-1/antagonists & inhibitors Thymosin. J Biol Chem 1986;261(13):5892
phosphofructokinase regulatory factors  0   *Peptides Phosphofructokinase-1. Arch Biochem Biophys 1984;235(2):504
phosphofructokinase regulatory subunit  EC 2.7.1.-   *Phosphofructokinase-1 Allosteric Regulation. FEBS Lett 1984;175(2):294

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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