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| A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
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Pharmacological Action Bronchodilator Agents; Neurotransmitter Agents; Endothelium-Dependent Relaxing Factors; Free Radical Scavengers
See Also Endothelium-Dependent Relaxing Factors; Nitric Oxide Donors | Other names Vasodilator, Endogenous Nitrate; Oxide, Nitric; Protoxide, Nitrogen; Nitric Oxide, Endothelium Derived; Nitrate Vasodilator, Endogenous; Monoxide, Nitrogen; Monoxide, Mononitrogen; Endothelium-Derived Nitric Oxide; Nitrogen Protoxide; Nitrogen Monoxide; Nitric Oxide, Endothelium-Derived; Mononitrogen Monoxide; Endogenous Nitrate VasodilatorDrugs* :
INOMAX
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| Substance | CAS Registry & name | Categories | Source | Drugs*
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5,6,7,8-tetrahydrobiopterin
| 17528-72-2
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Biopterin/*analogs & derivatives Nitric Oxide Nitric Oxide Synthase.
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Anal Biochem 89(1):71;1978; Ann Clin Lab Sci 7(2):178;1977; Arch Dis Child 53(8):674;1978; Arch Dis Child 54(5):329;1979; Biochem J 157(1):105;1976; Biochem J 171:267;1978; Biochim Biophys Acta 1980;611(1):241; Cancer Biochem Biophys 2(2):71;1978; Cancer Biochem Biophys 2(2):79;1978; Cancer Treat Rep 62(12):1999;1978; J Biol Chem 253(5):1598;1978; J Neural Transm 45(1):4;1979; J Neurochem 30:899;1978; J Neurochem 32(1):179;1979; J Neurochem 32(5):1575;1979; J Pediatr 1980;96(5):854; Lancet 1(7971):1236;1976; Lancet 1(8109):215;1979; Lancet 1(8115):556;1979; Lancet 1(8119):782;1979
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| PAPA NONOate
| 0
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*Hydrazines *Nitric Oxide.
Pharma Action Nitric Oxide Donors
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J Biol Chem 1998 May 29;273(22):13475-81
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2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid
| 0
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Oleanolic Acid/*analogs & derivatives Nitric Oxide/antagonists & inhibitors.
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Bioorg Med Chem Lett 1998 Oct 6;8(19):2711-4
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hemoglobin A, glycosylated-nitric oxide complex
| 0
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*Hemoglobin A, Glycosylated *Nitric Oxide.
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J Inorg Biochem 1988;34(1):19
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| myoglobin nitroxide
| 0
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*Myoglobin Nitric Oxide.
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J Biol Chem 1981;256(15):7849
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dipropylenetriamine-NONOate
| 0
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Nitric Oxide *Alkenes.
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Carcinogenesis 2002 Mar;23(3):469-75
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| nitric oxide naproxen
| 0
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*Nitric Oxide Naproxen/*analogs & derivatives.
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Life Sci 1998;62(15):PL 235-40
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2-(dimethylamino)ethylputreanine-nitric oxide adduct
| 0
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*Amino Acids, Diamino *Nitric Oxide Nitric Oxide Donors.
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J Appl Physiol 1997 Dec;83(6):1968-75
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ethylputreanine-nitric oxide adduct
| 0
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*Amino Acids, Diamino *Nitric Oxide Nitric Oxide Donors.
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J Appl Physiol 1997 Dec;83(6):1968-75
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| nitric oxide scavenger 100
| 0
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*Nitric Oxide.
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Transplantation 2000 Jan 27;69(2):227-31
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| nitrosonium tetrafluoroborate
| 14635-75-7
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*Borates *Nitric Oxide.
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FEBS Lett 1994 Jul 18;348(3):223-7
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| monomalonic acid C(60)
| 0
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*Malonates Nitric Oxide/antagonists & inhibitors.
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Gen Pharmacol 1997 Sep;29(3):345-51
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| nitrosonium ion
| 0
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*Nitric Oxide.
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Nitric Oxide 2004 Nov;11(3):256-62
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| prunioside A
| 0
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Nitric Oxide/antagonists & inhibitors *Glycosides *Terpenes.
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J Nat Prod 2001 Jul;64(7):942-4
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N(G)-hydroxy-arginine-nitric oxide adduct
| 0
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*Nitric Oxide Arginine/*analogs & derivatives.
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Proc Natl Acad Sci U S A 1995 May 9;92(10):4671-5
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| Roussin's red salt
| 58204-17-4
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*Nitric Oxide *Iron Compounds.
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Anal Biochem 1997 May 1;247(2):193-202
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| rhododendrol
| 0
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*Butanols Nitric Oxide/antagonists & inhibitors.
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Planta Med 1998 Oct;64(7):598-602
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1,5-bisacetoxy-8-angeloyloxy-3,4-epoxy-bisabola-7(14),10-dien-2-one
| 0
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*Sesquiterpenes Nitric Oxide/antagonists & inhibitors.
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J Nat Prod 1999 Oct;62(10):1437-8
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7-(N-4'-acetylphenylpiperazino)-8-cyano-4-chloropyrido(3',2'-4,5)thieno(3,2-d)-1,2,3-triazine
| 0
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*Thiophenes *Triazines Nitric Oxide/antagonists & inhibitors Dinoprostone/antagonists & inhibitors.
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J Med Chem 1999 Nov 4;42(22):4720-4
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8-cyano-4-(4-methylpiperidino)-7-morpholinopyrido(3',2'-4,5)thieno(3,2-d)-1,2,3-triazine
| 0
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*Thiophenes *Triazines Nitric Oxide/antagonists & inhibitors Dinoprostone/antagonists & inhibitors.
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J Med Chem 1999 Nov 4;42(22):4720-4
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methyl-N-2-dimethylaminoethyl-3-aminoproprionid-nitric oxide
| 0
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*Dimethylamines *Nitric Oxide.
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Crit Care Med 2005 Mar;33(3):616-22
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