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N-Formylmethionine Leucyl-Phenylalanine

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Definition: N-Formylmethionyl-leucyl-phenylalanine. A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.  DF: FMLP    Other names N-Formyl-Methionyl-Leucyl-Phenylalanine; F-Met-Leu-Phe; Peptide, N-Formylated; Peptide, Formylmethionyl; N Formylmethionine Leucyl Phenylalanine; N Formylated Peptide; N Formyl Methionyl Leucyl Phenylalanine; Leucyl-Phenylalanine, N-Formylmethionine; Formylmethionyl Leucyl Phenylalanine; Formylmet Leu Phe; F Met Leu Phe; N-Formylated Peptide; Formylmethionylleucylphenylalanine; Formylmethionyl-Leucyl-Phenylalanine; Formylmethionyl Peptide; Formylmet-Leu-Phe
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-formylmethionyl-leucyl-phenylalanine  0   *N-Formylmethionine Leucyl-Phenylalanine. J Physiol Pharmacol 2002 Dec;53(4 Pt 1):675-88
formyl-methionyl-2,3-didehydroleucyl-phenylalanine methyl ester  0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Cell Signal 2000 Jun;12(6):391-8
formyl-4-aminotetrahydrothiopyran-4-carbonyl-leucyl-phenylalanine methyl ester  0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Cell Signal 2000 Jun;12(6):391-8
formyl-methionyl-leucyl-2-aminoindane-2-carboxylic acid methyl ester  0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Cell Signal 2000 Jun;12(6):391-8
99mTc(fMLFK-HYNIC)(tricine)2  0   *Organotechnetium Compounds N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Bioconjug Chem 1999 Sep-Oct;10(5):884-91
formyl-Thp-leucyl-Ain-methyl ester  0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Biochim Biophys Acta 1997 Dec 12;1359(3):233-40
technetium Tc 99m N-acetylmethionyl-leucyl-phenylalanyl-lysyl-hydrazinonicotinamide  0   *Organotechnetium Compounds N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. J Nucl Med 1997 Aug;38(8):1316-22
technetium Tc 99m N-isobutyloxycarbonyl-methionyl-leucyl-phenylalanyl-lysyl-hydrazinonicotinamide  0   *Organotechnetium Compounds N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. J Nucl Med 1997 Aug;38(8):1316-22
formyl-methionyl-leucyl-2-aminooxy-3-phenylpropionic acid methyl ester  0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Pept Res 1996 Nov-Dec;9(6):279-82
formyl-methionyl-leucyl-N-methylphenylalanine methyl ester  0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Pept Res 1996 Nov-Dec;9(6):279-82
N-formylmethionyl-leucyl-phenylalanyl-tyrosine  0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Antisense Res Dev 1994 Summer;4(2):81-6
formyl-cyclo(cysteinyl-leucyl-phenylalanyl-cysteinyl) methyl ester  153824-53-4   *Peptides, Cyclic N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives Chemotaxis, Leukocyte. Arch Pharm (Weinheim) 1993 Dec;326(12):955-8
technetium Tc 99m formyl-methionyl-leucyl-phenylalanyl-lysyl-hydrazinonicotinamide  0   *Organotechnetium Compounds N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. J Nucl Med 1993 Dec;34(12):2176-81
2-(formyloxy)-4-(methylthio)butyryl-leucyl-phenylalanine methyl ester  151460-10-5   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives Chemotaxis, Leukocyte. Arch Pharm (Weinheim) 1993 Aug;326(8):461-5
N-formylmethionyl-prolyl-phenylalanine methyl ester  150178-44-2   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Int J Pept Protein Res 1993 Jun;41(6):595-605
formyl-methionyl-delta(Z)-dehydroleucyl-phenylalanine methyl ester  137320-56-0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Biopolymers 1993 Mar;33(3):437-51
N-formylmethionyl-leucyl-phenylalanyl-(N-dansyl)lysine  0   *Dansyl Compounds N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. J Cell Sci 1992 Oct;103 ( Pt 2):565-70
formylmethionyl-leucyl-alpha-methyl(phenylalanine) methyl ester  134574-90-6   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Pept Res 1991 Mar-Apr;4(2):66-71
N-formylmethionyl-leucyl-2-aminoindane-2-carboxylic acid phenylalanine methyl ester  134406-59-0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Int J Pept protein Res 1991;37(4):268
N-formylmethionine-thioamide-leucyl-phenylalanine methyl ester  99929-11-0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Int J Pept Protein Res 1990;36(6):489
N-formylmethionyl-leucyl-phenylalanyl tert-butyl ester  99880-61-2   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Int J Pept Protein Res 1990;36(6):489
squaric acid N-formylmethionyl-leucyl-phenylalanine methyl ester peptide conjugate  0   *Cyclobutanes N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. Res Commun Chem Pathol Pharmacol 1989;65(2):229
N-formyl-methionyl-leucyl-phenylalanyl-phenylalanine  80180-63-8   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. J Leukocytej Biol 1988;43(5):420
N-formylmethionyl-leucyl-phenylalanyl-lysine  81213-55-0   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives Chemotactic Factors. Clin Nephrol 1986;26(1):37
N-formyl-methionylleucyl-phenylalanyl-N(epsilon)-(2-(4-azidosalicylamido)ethyl-1,3'-dithiopropionyl)lysine  104234-99-3   *Azides N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Biochim Biophys Acta 1986;882(3):271
tert-butyloxycarbonyl-methionyl-leucyl-phenylalanine methyl ester  77542-78-0 L-Phenylalanine, N-(N-(N-((1,1-dimethylethoxy)carbonyl)-L-methionyl)-L-leucyl)-, (R)  N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives Chemotaxis, Leukocyte. Boll Soc Ital Biol Sper 1984;60(6):1103
formylmethionyl-leucyl-phenylalanine methyl ester  65929-03-5 L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-, (SP-4-2)  N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives Chemotaxis, Leukocyte. Boll Soc Ital Biol Sper 1984;60(6):1103
methionyl-leucyl-phenylalanine  59881-08-2   N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Int J Vitam Nutr Res 1984;54(1):47
N-formylmethionyl-leucyl-tyrosine  97521-28-3 L-Tyrosine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-, (+-)  N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Int J Vitam Nutr Res 1984;54(1):47
formylmethionyl-alpha-aminoisobutyryl-phenylalanine  89026-15-3 L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-2-methylalanyl)  N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. FEBS Lett 1984;165(2):171
N-formylmethionyl-cycloleucyl-phenylalanine  89026-13-1 L-Phenylalanine, N-formyl-L-methionyl-1-aminocyclopentanecarbonyl  N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. FEBS Lett 1984;165(2):171
N-formylmethionyl sulfoxide-leucyl-phenylalanine  77543-03-4 L-Phenylalanine, N-formyl-gamma-(methylsulfinyl)-L-alpha-aminobutyryl-L-leucyl  N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Biochem Biophys Res Commun 1982;109(1):194
N-formylmethionyl-methionyl-phenylalanine  59881-05-9 L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-methionyl)  N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives. Clin Exp Immunol 38(2):294;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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