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Lactoylglutathione Lyase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5.      Other names Methylglyoxalase; Lactoyl Glutathione Lyase; Glyoxalase I; Lyase, Lactoylglutathione; Lyase, Lactoyl Glutathione; I, Glyoxalase; Glutathione Lyase, Lactoyl
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
S-(N-hydroxy-N-p-iodophenylcarbamoyl)glutathione  0   Glutathione/analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. Biochemistry 1999 Oct 12;38(41):13480-90
S-(N-4-chlorophenyl-N-hydroxycarbamoyl)glutathione  0   Glutathione/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. J Med Chem 1999 May 20;42(10):1823-7
S-4-bromobenzylglutathione cyclopentyl diester  166038-00-2   Glutathione/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. Biochem Pharmacol 1996 May 17;51(10):1365-72
S-4-bromobenzylglutathione diethyl ester  146712-97-2   Glutathione/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. Biochem Pharmacol 1994 Jan 20;47(2):418-20
S-(N-phenylethylthiocarbamoyl)glutathione  0   *Thiocarbamates Glutathione/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. Biochem Soc Trans 1993 May;21(2):157S
S-(N-hydroxy-N-methylcarbamoyl)glutathione  144810-23-1   Glutathione/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. J Biol Chem 1992 Dec 15;267(35):24933-6
squaric acid N-formylmethionyl-leucyl-phenylalanine methyl ester peptide conjugate  0   *Cyclobutanes N-Formylmethionine Leucyl-Phenylalanine/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. Res Commun Chem Pathol Pharmacol 1989;65(2):229
S-benzylglutathione  6803-17-4   Glutathione/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. Biochem Biophys Res Commun 1985;128(1):360
hexylglutathione  24425-56-7   Glutathione/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Methods Enzymol 1981;77::231
S-(4-bromobenzyl)glutathione  31702-37-1 N-(S-((4-bromophenyl)methyl)-N-L-gamma-glutamyl-L-cysteinyl)glycine  Glutathione/*analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. FEBS Lett 102(1):162;1979
glutaryl-S-(4-bromobenzyl)cysteinylglycine  42583-87-9   *Dipeptides *Glutarates Lactoylglutathione Lyase/antagonists & inhibitors. J Med Chem 16(8):951;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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