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Keratins

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Definition: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.     
See Also Intermediate Filaments; Keratinocytes
Examples beta-Keratins; Keratins, Hair-Specific; Keratins, Type I; Keratins, Type II 		Other names Cytokeratin; alpha Keratin; Keratin Associated Proteins; Keratin-Associated Proteins; Keratin, Glycosylated; Keratin; Glycosylated Keratin; alpha-Keratin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ouro2 protein, Xenopus  0   *Keratins *Xenopus Proteins Antigens, Surface. Proc Natl Acad Sci U S A 2009 Oct 27;106(43):18309-14
Ouro1 protein, Xenopus  0   *Keratins *Xenopus Proteins Antigens, Surface. Proc Natl Acad Sci U S A 2009 Oct 27;106(43):18309-14
cytokeratin MNF116, human  0   *Keratins. Rom J Morphol Embryol. 2007;48(3); 291-4
keratin 77 protein, mouse  0   *Keratins. Dev Dyn 2007 Apr;236(4):961-70
Xlk2 protein, Xenopus  0   *Keratins *Xenopus Proteins. Biochim Biophys Acta 2006 May;1759(5):216-24
keratin-associated protein 5 family, human  0   *Cytoskeletal Proteins Hair Keratins. J Dermatol Sci 2006 Mar;41(3):221-4
Cyt1 protein, zebrafish  0   *Keratins *Zebrafish Proteins. Dev Dyn 2005 Jan;232(1):85-97
Krt20 protein, rat  0   *Keratins.
DAPK-1 protein, zebrafish  0   *Keratins *Zebrafish Proteins. Gene 2003 Jul 17;312:145-50
adult keratin-c, Xenopus  0   *Keratins *Xenopus Proteins. Dev Dyn 2002 Dec;225(4):561-70
D protein, Styela clava  0   *Keratins. Eur J Cell Biol. 2000 Jul;79(7):478-87
C protein, Styela clava  0   *Keratins. Eur J Cell Biol. 2000 Jul;79(7):478-87
CAM 5.2 antigen  0   *Keratins *Biological Markers. Am J Surg Pathol 1999 Nov;23(11):1349-55
CK-34 beta E12  0   *Keratins. Am J Surg Pathol 1999 Sep;23(9):1048-58
KRT1-17 protein, mouse  0   *Keratins. Genomics 1999 Mar 15;56(3):303-9
otokeratin protein, chicken  0   *Keratins *Avian Proteins. Proc Natl Acad Sci U S A 1998 Sep 15;95(19):11400-5
COU-1 antibody  0   *Antibodies, Monoclonal *Immunoglobulin Fab Fragments Keratins. Proc Natl Acad Sci U S A 1997 Jul 22;94(15):8110-5
bkj protein, Coturnix japonica  0   *Keratins. Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11731-5
cytokeratin peptide SFGSGFGGGY  0   *Keratins *Peptide Fragments. J Immunol 1994 Dec 15;153(12):5593-606
K2.13 protein, Ovis aries  0   *Keratins. DNA Seq 1993;3(6):401-5
pantogar  0   *Cysteine *Keratins *4-Aminobenzoic Acid *Pantothenic Acid *Thiamine *Yeast, Dried Drug Combinations Hair Preparations. Schweiz Rundsch Med Prax 1990;79(47)1457
merokeratin  0   *Keratins. Eur J Cell Biol 1980;23(1):110
prekeratin  0   *Keratins *Protein Precursors Intermediate Filament Proteins. Br J Dermatol 92:647;1975; Exp Cell Res 118(1):95;1979; J Biol Chem 248(13):4280;1973; J Cell Biol 1980;84(3):633; J Invest Dermatol 67:521;1976; Proc Natl Acad Sci USA 75(10):5034;1978
S-carboxymethylkerateine  37332-85-7 Protein SCMK-B 2C  *Keratins. Biochem J 128(5):1229;1972
keratohyalin  0   *Keratins RNA Hyalin. Curr Probl Dermatol 6:1;1976; J Cell Biol 52(2):453;1972; J Ultrastruct Res 41(5):550;1972; Tohoku J Exp Med 118(3):209;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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