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Ivermectin

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Definition: A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.     
Pharmacological Action Antiparasitic Agents; Insecticides 		Other names MK933; MK 933; Ivermectin Merck Brand; Stromectol; Merck Brand of Ivermectin; Mectizan; MK-933; Ivomec; EqvalanDrugs* : STROMECTOL; SKLICE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4'-amino-4'-avermectin B1 benzoate  0   Ivermectin/*analogs & derivatives. Environ Toxicol Chem 2010 Aug;29(8):1816-20
4''-oxo-avermectin  0   Ivermectin/*analogs & derivatives. Biochem Soc Trans 2006 Dec;34(Pt 6):1236-40
desmethylamino-emamectin B1a  0   *Disaccharides Ivermectin/*analogs & derivatives. J AOAC Int 2006 Nov-Dec;89(6):1672-6
emamectin  0   *Disaccharides Ivermectin/*analogs & derivatives. J Agric Food Chem 2001 Nov;49(11):5294-302
selamectin  0   Ivermectin/*analogs & derivatives.
Pharma Action Antiparasitic Agents 		Vet Parasitol 2000 Aug 23;91(3-4):163-76
22,23-dihydro-13-O-((2-methoxyethoxy)-methyl)abamectin B(1b) aglycone  0   Ivermectin/*analogs & derivatives. Xenobiotica 1997 Oct;27(10):985-94
22,23-dihydro-13-O-((2-methoxyethoxy)methyl)abamectin B(1a) aglycone  0   Ivermectin/*analogs & derivatives. Xenobiotica 1997 Oct;27(10):985-94
emamectin benzoate  137512-74-4   Ivermectin/*analogs & derivatives. Neurotoxicol Teratol 1997 Jul-Aug;19(4):315-26
4''-epiacetylamino-4''-deoxyavermectin B1  160902-72-7   Ivermectin/*analogs & derivatives.
Pharma Action Anthelmintics ; Insecticides 		Drug Metab Dispos 1996 May;24(5):572-8
L 648548  0   Ivermectin/*analogs & derivatives. J Pharm Sci 1996 Apr;85(4):446-50
UK 71647  0   Ivermectin/*analogs & derivatives Reference Standards. J Vet Pharmacol Ther 1995 Aug;18(4):290-8
6,8a-seco-6,8a-deoxyavermectin B1a aglycone  0   Ivermectin/*analogs & derivatives. J Antibiot (Tokyo) 1995 Jan;48(1):92-4
4'-deoleandrosyl-6,8a- seco-6,8a-deoxyavermectin B1a  0   Ivermectin/*analogs & derivatives. J Antibiot (Tokyo) 1995 Jan;48(1):92-4
4'-deoleandrosyl-6,8a-seco-6,8a-deoxyavermectin A1a  0   Ivermectin/analogs & derivatives. J Antibiot (Tokyo) 1995 Jan;48(1):92-4
doramectin  117704-25-3   Ivermectin/*analogs & derivatives.
Pharma Action Anthelmintics ; Anticonvulsants ; Insecticides ; Anti-Anxiety Agents 		Vet Parasitol 1993 Jul;49(1):5-15
4''-5,7-dimethylbodipypropionylivermectin  0   Ivermectin/*analogs & derivatives. Parasitol Res 1992;78(4):341-8
4''-epi-methylamino-4''-deoxyavermectin B1  119791-41-2   Ivermectin/*analogs & derivatives. Exp Appl Acarol 1992 Mar;13(4):249-59
27-hydroxyavermectin  109084-58-4   Ivermectin/*analogs & derivatives. J Ind Microbiol 1990;6(4):279
22,23-dihydroavermectin B(1a)-4''-(4-((4-(ethyl(1,2,3,4-tetrahydro-1,4-dioxo-6-phthalazinyl)amino)butyl)amino)-4-oxobutanoate)  122047-12-5   Ivermectin/*analogs & derivatives Luminol/*analogs & derivatives Luminescent Agents. Anal Biochem 1989;177(2):291
22,23-dihydroavermectin B(1)a  71827-03-7   Ivermectin/*analogs & derivatives. J Chromatogr 1987;413:326
abamectin  71751-41-2   Ivermectin/*analogs & derivatives.
Pharma Action Anthelmintics ; Insecticides 		Trans R Soc Trop Med Hyg 1985;79(6):797
demethylavermectins  0   Ivermectin/*analogs & derivatives. J Antibiot (Tokyo) 1985;38(11):1494
avermectin H2B1b  70209-81-3 Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)  Ivermectin/*analogs & derivatives. Drug Metab Dispos 1982;10(3):268
avermectin B2a  65195-57-5   Ivermectin/*analogs & derivatives. J Helminthol 1979;53(3):254
avermectin B(1)a  65195-55-3   Ivermectin/*analogs & derivatives.
Pharma Action Anthelmintics 		Am J Vet Res 40(8):1187;1979
avermectin  73989-17-0   Ivermectin/*analogs & derivatives.
Pharma Action Anthelmintics ; Antiprotozoal Agents ; Insecticides ; Excitatory Amino Acid Agonists 		Am J Vet Res 1979;40(7):1031; Am J Vet Res 1979;40(8):1187; Antimicrob Agents Chemother 15(3):361;1979; Eur J Pharmacol 56(3):273;1979; J Helminthol 52(4):305;1979; J Helminthol 52(4):308;1979; Proc Natl Acad Sci USA 76(4):2062;1979; Vet Rec 1979;105(8):168; Vet Rec 1980;108(3):59

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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