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Iron Chelating Agents

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Definition: Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.     
See Also Siderophores
Examples Siderophores 		Other names Iron Chelates; Chelating Agents, Iron; Chelates, Iron; Agents, Iron Chelating
Substances having this pharmacologic action: mycobactins; Fe(III)-EDTA; 3-hydroxy-4-pyridone; pyridoxal isonicotinoyl hydrazone; 1,10-phenanthroline; pyochelin; adenosine diphosphate-ferric chelate; tagatose; picolinic acid; Quin2; N-methyl-D-glucamine dithiocarbamate; pyoverdin; 2-pyrocatechuic acid; beta-thujaplicin; ferrioxamine B; Pentetic Acid; Ferrozine; exochelins; ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid); deferasirox; hydroxyethyl starch-deferoxamine conjugate; 1,2-diethyl-3-hydroxypyridin-4-one; deferiprone
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone  0   *Pyridines *Thiosemicarbazones Iron Chelating Agents. Mol Pharmacol 2011 Jun;79(6):921-31
ferro-N-dithiocarboxysarcosine  0   *Ferrous Compounds Iron Chelating Agents. Anal Biochem 2001 Nov 1;298(1):50-6
ferro-N-methyl-d-glucamide dithiocarbamate  0   *Ferrous Compounds Iron Chelating Agents. Anal Biochem 2001 Nov 1;298(1):50-6
CGP 65015  0   *Pyridines Iron Chelating Agents. Pharm Res 1999 Mar;16(3):434-40
membrane associated iron chelator  0   Organic Chemicals Iron Iron Chelating Agents Pseudomonas aeruginosa. Biochim Biophys Acta 1988;939(3):493
desferriferrithiocin  76045-30-2 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-, (S)  Pyridines Thiazoles Iron Chelating Agents. Exp Parasitol 1987;63(1):1

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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