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Iodide Peroxidase

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Definition: A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.  /defic: consider also MONOIODOTYROSINE /metab (IM) + AMINO ACID METABOLISM, INBORN ERRORS (IM) + CONGENITAL HYPOTHYROIDISM    Other names Thyroxine 5'-Monodeiodinase; Thyroxine 5'-Deiodinase; Thyroid Peroxidase; Iodotyrosine Deiodase; Iodothyronine Deiodinase; Iodothyronine 5'-Deiodinase; Iodinase; Triiodothyronine 5'-Deiodinase, Reverse; Thyroxine 5' Monodeiodinase; Thyroxine 5' Deiodinase; Tetraiodothyronine 5' Deiodinase; T4 Monodeiodinase; T4 5' Deiodinase; Reverse Triiodothyronine 5' Deiodinase; Peroxidase, Thyroid; Peroxidase, Iodide; Iodothyronine 5' Deiodinase; Enzyme, Thyroxine Converting; Deiodinase, Triiodothyronine; Deiodinase, Iodotyrosine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
selenodeiodinase type 1, mouse  EC 1.11.1.8   *Iodide Peroxidase. Endocrinology 2006 Jan;147(1):580-9
vanadium iodoperoxidase  EC 1.11.1.-   *Iodide Peroxidase. Phytochemistry 2000 May;54(1):5-11
iodothyronine deiodinase type III  EC 1.11.1.-   *Iodide Peroxidase. Endocrinology 1999 Feb;140(2):844-51
iodothyronine deiodinase type I  EC 1.11.1.-   *Iodide Peroxidase. Biochem Biophys Res Commun 1997 Dec 18;241(2):459-64
EMD 49209  0   *Flavonoids Iodide Peroxidase/antagonists & inhibitors. Endocrinology 1997 Jan;138(1):79-84
iodothyronine deiodinase type II  EC 1.11.1.-   *Iodide Peroxidase. Endocrinology 1996 Aug;137(8):3308-15
6-methyl-2-selenouracil  22384-57-2   *Organoselenium Compounds Uracil/*analogs & derivatives Iodide Peroxidase/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Dec 30;189(3):1362-7
6-propyl-2-selenouracil  126632-05-1   *Organoselenium Compounds Uracil/*analogs & derivatives Iodide Peroxidase/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Dec 30;189(3):1362-7
3',5'-dibromo-2',4,4',6-tetrahydroxyaurone  126985-05-5   *Benzofurans Iodide Peroxidase/antagonists & inhibitors. Proc Natl Acad Sci U S A 1992 Jul 15;89(14):6644-8
3-methyl-4',6-dihydroxy-3',5'-dibromoflavone  104567-72-8   *Flavonoids Iodide Peroxidase/antagonists & inhibitors. Prog Clin Biol Res 1988;280:323
TPO protein, human  EC 1.11.1.7   *Autoantigens *Iodide Peroxidase *Iron-Binding Proteins. Endocrinology 1988;123(2):1140
fenvalerate  51630-58-1 4-chloro-alpha-(1-methylethyl)benzeneacetic acid cyano(3-phenoxyphenyl)methyl ester  *Nitriles *Pyrethrins Iodide Peroxidase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Insecticides 		Bull Environ Contam Toxicol 1980;24(2):283; J Assoc Off Anal Chem 60(4):908;1977; J Assoc Off Anal Chem 61(4):869;1978; J Econ Entomol 1979;72(2):215

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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