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Insulin-Like Growth Factor I

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Definition: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.     
See Also Receptor, IGF Type 1 		Other names Somatomedin C; IGF-I; Insulin Like Somatomedin Peptide I; Insulin-Like Somatomedin Peptide I; Insulin Like Growth Factor I; IGF-I-SmC; IGF-1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
insulin-like growth factor-1, rat  0   *Insulin-Like Growth Factor I. Int J Dev Neurosci. 2010 Feb;28(1):91-7
IGF-I-IGFBP-3 complex  0   *Insulin-Like Growth Factor I *Insulin-Like Growth Factor Binding Protein 3. Horm Res. 2009;72(1); 46-51IPLEX
Peptide growth factors deficiency  0   *Werner Syndrome Epidermal Growth Factor/deficiency Insulin-Like Growth Factor I/deficiency.
mechano-growth factor, mouse  0   *Insulin-Like Growth Factor I. Dokl Biochem Biophys 2007 Nov-Dec;417();337-40
mechano-growth factor E, human  0   *Insulin-Like Growth Factor I. Am J Transplant 2007 Oct;7(10):2247-59
insulin-like growth factor-1, mouse  0   *Insulin-Like Growth Factor I. Breast Cancer Res 2007;9(1):R1
mechano-growth factor, rat  0   *Insulin-Like Growth Factor I Protein Isoforms. J Physiol 1999 Apr 15;516( Pt 2):583-92
Nalpha(Gly1)-((2-6-(biotinamido)-2-(4-azidobenzamido)hexanoamido)ethyl-1.'-dithiopropionyl)-insulin-like growth factor-1  0   *Azides Insulin-Like Growth Factor I/*analogs & derivatives. J Biol Chem 2001 Jan 26;276(4):2880-9
Nalpha(Gly1)-(4-azidobenzoyl)-insulin-like growth factor-1  0   *Azides Insulin-Like Growth Factor I/*analogs & derivatives. J Biol Chem 2001 Jan 26;276(4):2880-9
picropodophyllin  0   Podophyllotoxin/*analogs & derivatives Insulin-Like Growth Factor I Podophyllum. J Org Chem. 2000 Feb 11;65(3):847-60
pro-insulin-like growth factor I  0   *Insulin-Like Growth Factor I *Protein Precursors. Endocrinology 1999 Jul;140(7):3387-90
cementum-derived growth factor, 14-kDa  0   *Insulin-Like Growth Factor I Dental Cementum Growth Substances. FASEB J 1998 Sep;12(12):1233-9
Humatrix  0   *Epidermal Growth Factor *Insulin-Like Growth Factor I Gels. Cancer Lett 1998 Jan 30;123(2):215-26
insulin-like growth factor-1 D peptide  0   Insulin-Like Growth Factor I/analogs & derivatives. FASEB J 1995 Oct;9(13):1336-44
insulin-like growth factor I, Gln(3)-Ala(4)-Tyr(15)-Leu(16)  0   Insulin-Like Growth Factor I/*analogs & derivatives. Biochem Biophys Res Commun 1995 Jul 6;212(1):242-8
preproinsulin-like growth factor I  0   *Insulin-Like Growth Factor I *Protein Precursors Growth Substances. Endocrinology 1995 May;136(5):1939-44
insulin-like growth factor I (24-41)  0   *Insulin-Like Growth Factor I *Peptide Fragments. Brain Res Bull 1994;35(4):367-71
long R(3)-insulin-like growth factor-I  0   Insulin-Like Growth Factor I/*analogs & derivatives. J Endocrinol 1993 Nov;139(2):259-65
LR(3)IGF-I  0   Insulin-Like Growth Factor I/*analogs & derivatives. J Endocrinol 1993 Aug;138(2):327-36
insulin-like growth factor I-Pseudomonas exotoxin A (40)  0   *Exotoxins *Insulin-Like Growth Factor I. J Neurosurg 1993 Oct;79(4):569-76
insulin-like growth factor I, N-Ala-Glu  0   Insulin-Like Growth Factor I/*analogs & derivatives Recombinant Proteins. Protein Eng 1992 Dec;5(8):797-806
human insulin-like-growth-factor-I (21-40)  141472-16-4   *Insulin-Like Growth Factor I *Peptide Fragments. Biochem J 1992 Apr 15;283( Pt 2):473-8
insulin like growth factor I (1-27)-Gly-Gly-Gly-Gly-(38-70)  131595-85-2   Insulin-Like Growth Factor I/*analogs & derivatives. Endocrinology 1990;127(6):3243
insulin-like growth factor I, N-methionyl  106768-76-7   Insulin-Like Growth Factor I/*analogs & derivatives. Mol Cell Endocrinol 1989;66(1):37
insulin-like growth factor 1, des-(1-3)  112603-35-7   *Insulin-Like Growth Factor I *Peptide Fragments. Biochem J 1989;258(1):267
insulin-like growth factor I (57-70)  123618-03-1   *Insulin-Like Growth Factor I *Peptide Fragments. Horm Metab Res 1988;20(6):344
insulin-like growth factor 1A prohormone (91-103)  0   *Insulin-Like Growth Factor I *Peptide Fragments. J Clin Endocrinol Metab 1987;65(5):869
insulin-like growth factor I, Val(59)  97199-04-7   Insulin-Like Growth Factor I/*analogs & derivatives. Ann NY Acad Sci 1986;469:31
insulin-like growth factor I, Thr(59)  97199-03-6   Insulin-Like Growth Factor I/*analogs & derivatives. J Clin Endocrinol Metab 1986;62(6):1206
insulin, A(27)-B-insulin-like growth factor I  100214-40-2   Insulin/*analogs & derivatives Insulin-Like Growth Factor I/*analogs & derivatives. Biochem Biophys Res Commun 1985;133(2):423

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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