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Hydroxyestrones

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Definition: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-hydroxyestrone N-acetylcysteine  0   *Acetylcysteine *Hydroxyestrones. Steroids 1998 Dec;63(12):672-7
3-hydroxy-1-methyl-1,3,5(10)-estratriene-11,17-dione  55675-00-8   *Hydroxyestrones. Acta Crystallogr C 1990;46(Pt 6):1172
STS 267  51946-38-4 Estra-1,3,5(10)-trien-17-one, 16-azido-3-methoxy-, (16alpha)  *Azides *Hydroxyestrones. Pharmazie 1988;43(5):329
7-hydroxyestrone  2487-49-2   *Hydroxyestrones. Steroids 1983;41(5):597
6-hydroxyestrone  1476-78-4   *Hydroxyestrones. Steroids 1983;41(5):597
6 alpha,16 alpha-dihydroxyestrone 6-hemisuccinate  84371-31-3 Estra-1,3,5(10)-trien-17-one, 6-(3-carboxy-1-oxopropoxy)-3,16-dihydroxy-, (6alpha,16alpha)  *Hydroxyestrones. Steroids 1982;39(5):557
4-hydroxyestrone-4-methyl ether  58562-33-7 Estra-1,3,5(10)-trien-17-one, 3-hydroxy-4-methoxy  *Hydroxyestrones. Horm Metab Res 1982;14(7):376
estrone 3-bromoacetate  81949-03-3 Estra-1,3,5(10)-trien-17-one, 3-((bromoacetyl-2-14C)oxy)  *Hydroxyestrones. Steroids 1982;39(2):165
14-hydroxyestrone  5949-46-2   *Hydroxyestrones. Cas Lek Cesk 1981;120(20):616
11-hydroxyestrone  6803-21-0   *Hydroxyestrones. Steroids 1981;37(3):243
4-hydroxyestrone-3-methyl ether  5976-62-5   *Hydroxyestrones Estrogens, Catechol. Hoppe-Seylers Z Physiol Chem 1980;361(11):1743
4-hydroxyestrone-17-(O-carboxymethyl)oxime  77111-07-0 Acetic acid, (((3,4-dihydroxyestra-1,3,5(10)-trien-17-ylidene)amino)oxy)  *Hydroxyestrones Estrogens, Catechol. Hoppe Seylers Z Physiol Chem 1980;361(11):1743
16-hydroxyestrone  18186-49-7   *Hydroxyestrones. J Clin Endocrinol Metab 1980;51(3):611
4-hydroxyestrone  3131-23-5   *Hydroxyestrones Estrogens, Catechol. Steroids 1980;36(1):73
2-hydroxyestrone  362-06-1 Estra-1,3,5(10-trien-17-one, 2,3-dihydroxy)  *Hydroxyestrones Estrogens, Catechol.
Pharma Action Anticarcinogenic Agents
J Steroid Biochem 1980;13(1):83
16-hydroxyestrone 3-sulfate  0   *Hydroxyestrones. Steroids 1981;38(5):557
colpormon  1247-71-8 (16 alpha)- 3,16-bis(acetyloxy)estra-1,3,5(10)-trien-17-one  *Hydroxyestrones. Nippon Naibunpi Gakkai Zasshi 55(5):678;1979
3-methoxy-17-hydroxyestra-1,3,5(10)-trien-16-one oxime  0   *Hydroxyestrones. J Org Chem 42(12):2101;1977
2,4-dihydroxyestrone  42979-86-2 Estra-1,3,5(10)-trien-17-one, 2,3,4-trihydroxy  *Hydroxyestrones. Hoppe Seylers Z Physiol Chem 357(1):81;1976
3-methoxy-14 alpha-hydroxy-8 alpha-estra-1,3,5(10)- triene-11,17-dione  0   *Hydroxyestrones. J Org Chem 39(15):2193;1974
15 alpha-hydroxyestrone 3-sulfate 15-N-acetylglucosaminide  25577-72-4 15 alpha-((2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)oxy)-3-(sulfooxy)estra-1,3,5(10)-trien- 17-one  *Hydroxyestrones. J Clin Endocrinol Metab 38(2):215;1974
2-hydroxyestrone 2,3-methylene ether  53573-94-7 Estra-1,3,5(10)-trien-17-one, 2,3-(methylenebis(oxy))  *Hydroxyestrones Estrogens, Catechol. Steroids 23(6):869;1974
2,16 alpha-dihydroxyestrone 3-methyl ether  42241-06-5   *Hydroxyestrones. Chem Pharm Bull (Tokyo) 21(4):914;1973; Chem Pharm Bull (Tokyo) 23(7):1613;1975
2-methoxyestrone  362-08-3 3-hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one  *Hydroxyestrones. Steroids 1979;34(5):485; Steroids 33(5):563;1979
6 beta-hydroxyestr-4-ene-3,17-dione  5949-49-5   *Hydroxyestrones. J Biol Chem 248(6):2134;1973
2-methoxyestrone-3-glucuronide  25577-70-2   *Hydroxyestrones.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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