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Histidine Decarboxylase

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Definition: An enzyme that catalyzes the decarboxylation of histidine to histamine and carbon dioxide. It requires pyridoxal phosphate in animal tissues, but not in microorganisms. EC 4.1.1.22.      Other names Histidine Carboxy-Lyase; Histidine Carboxy Lyase; Decarboxylase, Histidine; Carboxy-Lyase, Histidine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pyridoxyl-histidine methyl ester  0   Histidine/*analogs & derivatives Pyridoxic Acid/*analogs & derivatives Histidine Decarboxylase/antagonists & inhibitors. FASEB J 2008 Mar;22(3):890-7
shoyuflavone B  0   *Flavonoids Histidine Decarboxylase/antagonists & inhibitors. Biosci Biotechnol Biochem 1998 Aug;62(8):1488-91
shoyuflavone A  0   *Flavonoids Histidine Decarboxylase/antagonists & inhibitors. Biosci Biotechnol Biochem 1998 Aug;62(8):1488-91
TOM 92 protein, Lycopersicon esculentum  0   *Plant Proteins Histidine Decarboxylase. Plant Mol Biol 1993 Nov;23(3):627-31
alpha-fluoromethylhistamine  69672-40-8   Histamine/*analogs & derivatives Histidine Decarboxylase/antagonists & inhibitors. Pharmacol Biochem Behav 1987;28(3):419
3-O-methylcatechin  87367-19-9 2H-1-benzopyran-5,7-diol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-3-methoxy  Catechin/*analogs & derivatives Histidine Decarboxylase/antagonists & inhibitors.
Pharma Action Anti-Ulcer Agents ; Enzyme Inhibitors 		Drug Metab Dispos 1981;9(1):54
alpha-fluoromethylhistidine  70050-43-0 histidine, alpha-(fluoromethyl)  *Methylhistidines Histidine Decarboxylase/antagonists & inhibitors.
Pharma Action Antiemetics ; Enzyme Inhibitors 		J Neurochem 1980;35(5):1045
AIS 48  58489-32-0 (+/-)-alpha-hydrazino-3,4-dihydro-2(1H)-isoquinolinebutanoic acid  *Tetrahydroisoquinolines Histidine Decarboxylase/antagonists & inhibitors. Arzneim Forsch 26(1):62;1976; Arzneim Forsch 27(3):620;1977
lecanoric acid  480-56-8 2,4-dihydroxy-6-methylbenzoic acid 4-carboxy-3-hydroxy-5-methylphenyl ester  *Salicylates Histidine Decarboxylase/antagonists & inhibitors. J Antibiot (Tokyo) 27(8):587;1974; Tanpakushitsu Kakusan Koso 21(10):785;1976
2-hydroxy-5-carbomethoxybenzyloxyamine  38573-39-6 3-((aminooxy)methyl)-4-hydroxybenzoic acid methyl ester  *Parabens Histidine Decarboxylase/antagonists & inhibitors. Biochem Pharmacol 22(18):2253;1973
alpha-chloro-beta-imidazol-4(5)-ylpropionic acid  6630-42-8 1H-Imidazole-4-propanoic acid, alpha-chloro  *Imidazoles Histidine Decarboxylase/antagonists & inhibitors. Arch Int Pharmacodyn 208(2):289;1974
4-imidazolyl-3-amino-2-butanone  24579-23-5 3-amino-4-(1H-imidazol-4-yl)-2-butanone  *Butanones *Imidazoles Histidine Decarboxylase/antagonists & inhibitors. Agents Actions 7(2):237;1977; Biochem Pharmacol 22(18):2299;1973
MK 785  14760-71-5 alpha-hydrazino-1H-imidazole-4-propanoic acid  *Imidazoles Histidine Decarboxylase/antagonists & inhibitors. Arzneim Forsch 26(1):62;1976; Biochim Biophys Acta 444(1):294;1976; N Eng J Med 288(11):545;1973
thiazol-4-ylmethoxyamine  35285-42-8   *Thiazoles Histidine Decarboxylase/antagonists & inhibitors. Experientia 32(10):1313;1976; Life Sci 10(19):1097;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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