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Fructose-Bisphosphate Aldolase

More information in Books or onNLM PubMed
Definition: An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.  /defic: consider also FRUCTOSE INTOLERANCE   
See Also Fructose Intolerance 		Other names Fructosediphosphate Aldolase; Aldolase; Fructose Bisphosphate Aldolase; Fructose 1,6 Bisphosphate Aldolase; Fructose 1 Phosphate Aldolase; Aldolase, Fructosemonophosphate; Aldolase, Fructosediphosphate; Aldolase, Fructose-Bisphosphate; Aldolase, Fructose Biphosphate; Aldolase, Fructose 1-Phosphate; Aldolase, Fructose 1,6-Bisphosphate; 1,6-Bisphosphate Aldolase, Fructose; Fructosemonophosphate Aldolase; Fructose Biphosphate Aldolase; Fructose 1-Phosphate Aldolase; Fructose 1,6-Bisphosphate Aldolase, Class II; Fructose 1,6-Bisphosphate Aldolase; Aldolase C; Aldolase B; Aldolase A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,6-dihydroxynaphthalene-1-carboxaldehyde 6-phosphate  0   *Naphthols *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. J Med Chem 2006 Mar 9;49(5):1499-502
1,6-dihydroxy-2-naphthaldehyde 6-phosphate  0   *Naphthols *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Biochemistry 2005 Apr 12;44(14):5430-43
fucA protein, E coli  EC 4.1.2.-   *Fructose-Bisphosphate Aldolase *Escherichia coli Proteins.
antibody aldolase  EC 4.1.2.-   *Fructose-Bisphosphate Aldolase *Immunoglobulin Fab Fragments Antibodies, Catalytic.
resorcinol bisphosphate  0   *Phosphoric Acid Esters *Resorcinols Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Biochem J 1997 Apr 1;323( Pt 1):71-7
4-hydroxybenzaldehyde phosphate  0   *Benzaldehydes *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Biochem J 1997 Apr 1;323( Pt 1):71-7
hydroquinone 1,4-bisphosphate  0   *Hydroquinones *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Biochem J 1997 Apr 1;323( Pt 1):71-7
2,4-dihydroxybenzaldehyde 4-phosphate  0   *Benzaldehydes *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Biochem J 1997 Apr 1;323( Pt 1):71-7
2-(2-hydroxyphenyl)-2-oxoethyl phosphate  0   *Acetophenones *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Bioorg Med Chem 1996 Dec;4(12):2043-54
1-(phosphonooxy)-2,4-pentanedione  157247-71-7   *Pentanones *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Bioorg Med Chem 1996 Dec;4(12):2043-54
(2,4-dioxo)butyl phosphate  0   *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Bioorg Med Chem 1996 Dec;4(12):2043-54
FucA protein, bacteria  EC 4.1.2.-   *Bacterial Proteins *Fructose-Bisphosphate Aldolase. Structure 1996 Nov 15;4(11):1303-15
3-hydroxypropane-1-phosphate  13507-42-1   *Phosphoric Acid Esters *Propylene Glycols Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Bioorg Med Chem 1995 Sep;3(9):1247-53
erythrulose 1-phosphate  16409-92-0   *Sugar Phosphates Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Biochem Biophys Res Commun 1991;176(1):511
2-keto-4,4,4-trifluorobutyl phosphate  93383-53-0   *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. Biochemistry 1984;23(26):6858
citraconyl-aldolase  EC 4.1.2.-   *Fructose-Bisphosphate Aldolase. Biochem J 139(2):331;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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