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Estrogens, Conjugated (USP)

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Definition: A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.  do not confuse with ESTRADIOL CONGENERS   
Pharmacological Action Estrogens 		Other names Estrogenic Substances, Conjugated; Equine Estrogens, Conjugated; Conjugated Estrogenic Substances; Conjugated Estrogenic Hormones; Wyeth Brand of Estrogens, Conjugated; Trianon Brand of Estrogens, Conjugated; Transannon; Solvay Brand of Estrogens, Conjugated; Progens; Presomen; Premarin; Prelestrin; Pharmacia Brand of Estrogens, Conjugated (USP); Pasadena Brand of Estrogens, Conjugated (USP); Oestrofeminal; Oestro-Feminal; Major Brand of Estrogens, Conjugated (USP); Mack Brand of Estrogens, Conjugated (USP); Femavit; Estrogens, ConjugatedDrugs* : MILPREM-200; PMB 200; PREMARIN; MILPREM-400; PMB 400
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Prempro  0   *Estrogens, Conjugated (USP) *Medroxyprogesterone Acetate Drug Combinations. JAMA 2002 Oct 2;288(13):1579PREMPHASE (PREMARIN;CYCRIN 14/14); PREMPRO; PREMPHASE 14/14; PREMPRO/PREMPHASE; PREMPRO (PREMARIN;CYCRIN)
delta-8-estrone sulfate  0   Estrone/*analogs & derivatives Estrogens, Conjugated (USP). J Soc Gynecol Investig 1998 May-Jun;5(3):156-60
Premaril Plus  0   *Estrogens, Conjugated (USP) *Medroxyprogesterone Acetate Estrogen Replacement Therapy. Eur J Obstet Gynecol Reprod Biol 1992 Sep 23;46(2-3):109-16
estriol 17-sulfate  42028-21-7   Estriol/*analogs & derivatives Estrogens, Conjugated (USP). J Steroid Biochem 1986;24(1):357
estradiol 17-sulfate  3233-69-0   Estradiol/*analogs & derivatives Estrogens, Conjugated (USP). Steroids 1985;45(3-4):303
estradiol 3,17-disulfate  3233-70-3   Estradiol/*analogs & derivatives Estrogens, Conjugated (USP). Steroids 1984;43(6):603
estradiol-bovine serum albumin  0   *Estradiol *Serum Albumin, Bovine Estrogens, Conjugated (USP). Histochem J 1984;16(9):1003
estradiol 6-O-carboxymethyloxime-bovine serum albumin-fluorescein isothiocyanate  0   *Serum Albumin, Bovine Estradiol/*analogs & derivatives Fluorescein-5-isothiocyanate/*analogs & derivatives Estrogens, Conjugated (USP). Histochem J 1984;16(9):1003
estradiol 17-hemisuccinate-bovine serum albumin-fluorescein isothiocyanate  0   *Serum Albumin, Bovine Estradiol/*analogs & derivatives Fluorescein-5-isothiocyanate/*analogs & derivatives Estrogens, Conjugated (USP). Histochem J 1984;16(9):1003
estrone-17-oxime-bovine serum albumin  0   *Serum Albumin, Bovine Estrone/*analogs & derivatives Estrogens, Conjugated (USP). J Anim Sci 1984;59(1):189
estradiol-17-glucosiduronate-(C-6)-bovine serum albumin conjugate  0   *Serum Albumin, Bovine Estradiol/*analogs & derivatives Estrogens, Conjugated (USP). Acta Endocrinol 1984;106(3):374
CAMFTP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Estrogens, Conjugated (USP) Fluorouracil Methotrexate Tamoxifen. J Clin Oncol 1984;2(1):28
equilin sulfate  27540-07-4   Equilin/*analogs & derivatives Estrogens, Conjugated (USP). J Clin Endocrinol Metab 1983;56(5):1048
Seda-Presomen  81296-87-9 Seda-presomen  *Diazepam *Estrogens, Conjugated (USP) Drug Combinations. Acta Univ Palacki Olomuc Fac Med 1981;101:139
estradiol sulfate  28814-94-0   Estradiol/*analogs & derivatives Estrogens, Conjugated (USP). J Clin Endocrinol 1981;53(2):418
estradiol-3-sulfate  481-96-9   Estradiol/*analogs & derivatives Estrogens, Conjugated (USP). J Steroid Biochem 1980;13(12):1401
estriol 3-glucuronide  2479-91-6 (16 alpha,17 beta)-16,17-dihydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid  Estriol/*analogs & derivatives Estrogens, Conjugated (USP). J Clin Endocrinol Metab 50(1):137;1980
estrone sulfate  481-97-0   Estrone/*analogs & derivatives Estrogens, Conjugated (USP). Biochimie 60(8):795;1978; Biol Reprod 19(1):202;1978; Contraception 6(5):412;1972; Endocrinology 103(4):1227;1978; Endocrinology 1980;106(4):1079; Endocrinology 1980;106(4):1193; Steroids 1979;34(5):563; Steroids 1979;34(6):649EVEX
17 alpha-ethynylestradiol-17 beta-D-glucopyranosiduronic acid  75803-39-3 beta-D-Glucopyranosiduronic acid, (17alpha)-3-hydroxy-19-norpregna-1,3,5(10)-trien-20-yn-17-yl  Ethinyl Estradiol/*analogs & derivatives Estrogens, Conjugated (USP). J Steroid Biochem 9(3):237;1978
estrone-3-glucuronide  2479-90-5   Estrone/*analogs & derivatives Estrogens, Conjugated (USP). Endocrinol Jpn 24(5):503;1977; J Steroid Biochem 6(11):1477;1975; Steroids 1979;34(4):445
estradiol valerate  979-32-8   Estradiol/*analogs & derivatives Estrogens, Conjugated (USP).
Pharma Action Contraceptive Agents 		Acta Obstet Gynecol Scand 56(4):363;1977; Acta Obstet Gynecol Scand 56(4):367;1977; Arch Ostetric Ginecolog 79(5-6):336;1974; Cancer Res 38(11):4073;1978; Endocrinology 103(2):501;1978DITATE-DS; ESTRADIOL VALERATE; TESTOSTERONE ENANTHATE AND ESTRADIOL VALERATE; DELESTROGEN
estriol-16 alpha-(beta-D-glucuronide)  1852-50-2   Estriol/*analogs & derivatives Estrogens, Conjugated (USP). Am J Obstet Gynecol 125(6):841;1976; J Chromatogr 145(3):478;1978; J Clin Endocrinol Metab 1979;50(1):137; Steroids 1979;34(4):445
estriol-16,17-disuccinyl-bovine serum albumin  0   *Serum Albumin, Bovine Estriol/*analogs & derivatives Estrogens, Conjugated (USP). Am J Obstet Gyn 123(7):700;1975
2,4,17 alpha-d(3)-estriol 3-glucuronoside  0   Estriol/*analogs & derivatives Estrogens, Conjugated (USP). Chem Pharm Bull 22(12):3002;1975
estropipate  7280-37-7 estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, compd. with piperazine (1:1)  Estrone/*analogs & derivatives Estrogens, Conjugated (USP).
Pharma Action Contraceptive Agents 		Curr Med Res Opin 2(7):417;1974; Curr Med Res Opin 4(4):303;1976; IARC Monogr Eval Carcinog Risk Chem Hum1979;21:147; Practitioner 218(1306):573;1977OGEN 1.25; OGEN .625; ESTROPIPATE; OGEN 2.5; OGEN 5; ORTHO-EST; OGEN
formatrix  77630-33-2 L-Ascorbic acid, mixt. with estrogen conjugates and (17beta)-17-hydroxy-17-methylandrost-4-en-3-one  *Ascorbic Acid *Estrogens, Conjugated (USP) *Methyltestosterone Drug Combinations.
estradiol-17 beta-succinyl-bovine serum albumin  0   *Serum Albumin, Bovine Estradiol/*analogs & derivatives Estrogens, Conjugated (USP). Biology Reprod 5(3):340;1971
Ovaribran  78408-03-4   *Estrogens, Conjugated (USP) *Oxazepam Drug Combinations. Z Allgemeinmed 46(1):48;1970

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