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Dimethylallyltranstransferase

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Definition: An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.      Other names Prenyltransferase; Geranylpyrophosphate Synthetase; Farnesylpyrophosphate Synthetase; Dimethylallyltransferase; Synthetase, Nerylpyrophosphate; Synthetase, Geranylpyrophosphate; Synthetase, Geranylgeranyl Pyrophosphate; Synthetase, Farnesylpyrophosphate; Synthetase, Dolichyl Phosphate; Pyrophosphate Synthetase, Geranylgeranyl; Phosphate Synthetase, Dolichyl; Nerylpyrophosphate Synthetase; Geranylgeranyl Pyrophosphate Synthetase; Dolichyl Phosphate Synthetase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NovQ protein, Streptomyces  EC 2.1.1.-.   *Bacterial Proteins *Dimethylallyltranstransferase. J Antibiot (Tokyo). 2009 Jul;62(7):385-92
CdpNPT protein, Aspergillus fumigatus  EC 2.5.1.1   *Dimethylallyltranstransferase Fungal Proteins. J Nat Prod 2009 Jan;72(1):44-52
FtmPT1 protein, Aspergillus fumigatus  EC 2.5.1.1   *Dimethylallyltranstransferase Fungal Proteins. J Nat Prod 2009 Jan;72(1):44-52
phenethylaminomethanone-A  0   *Benzophenones Dimethylallyltranstransferase/antagonists & inhibitors. J Med Chem 2007 Aug 23;50(17):3973-5
allylaminomethanone-A  0   *Benzophenones Dimethylallyltranstransferase/antagonists & inhibitors. J Med Chem 2007 Aug 23;50(17):3973-5
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, Sulfolobus solfataricus  EC 2.5.1.-   *Dimethylallyltranstransferase. Org Lett 2006 Mar 2;8(5):943-6
4-hydroxybenzoic acid oligoprenyltransferase, E coli  EC 2.5.1.1   *Dimethylallyltranstransferase. J Mol Model (Online) 2004 Dec;10(5-6):317-27
fumigaclavine C synthase  EC 2.5.1.1   *Dimethylallyltranstransferase. Chembiochem. 2006 Jan;7(1):158-64
quemao protein, Drosophila  EC 2.5.1.1   *Dimethylallyltranstransferase *Drosophila Proteins.
GGPS1 protein, human  EC 2.5.1.29   *Dimethylallyltranstransferase *Geranyltranstransferase *Farnesyltranstransferase.
PLMP protein, mouse  EC 2.5.1.1   *Dimethylallyltranstransferase *Mitochondrial Proteins. Kidney Int 2004 Jul;66(1):20-8
RER2 protein, S cerevisiae  EC 2.5.1.1   *Dimethylallyltranstransferase *Saccharomyces cerevisiae Proteins. Traffic 2003 Sep;4(9):607-17

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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