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Desoxycorticosterone

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Definition: 21-Hydroxypregn-4-ene-3,20-dione. Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.  do not coordinate with ACETATES for DOCA; do not confuse trade name Decortin (Schieffelin) with PREDNISONE trade name Decortin (Merck)   
Pharmacological Action Mineralocorticoids
Examples 18-Hydroxydesoxycorticosterone 		Other names Desoxycortone; Desoxycorticosterone Acetate; Deoxycorticosterone; DOCA; Cortexone; 21-Hydroxyprogesterone; Acetate, Desoxycorticosterone; 21 Hydroxyprogesterone; 21 Hydroxy 4 pregnene 3,20 dione; 11 Decorticosterone; Decortin; 21-Hydroxy-4-pregnene-3,20-dione; 11-DecorticosteroneDrugs* : PERCORTEN; DOCA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
21-hydroxy-6,19-epithiopregn-4-ene-3,20-dione  0   Desoxycorticosterone/*analogs & derivatives. J Med Chem 2005 Sep 8;48(18):5675-83
19-acetylenic-deoxycorticosterone  127080-69-7   Desoxycorticosterone/*analogs & derivatives. Am J Hypertens 1992 Jun;5(6 Pt 1):372-7
18-ethynyldeoxycorticosterone  80899-91-8 18-Norpregn-4-ene-3,20-dione, 21-hydroxy-13-(2-propynyl)  Desoxycorticosterone/*analogs & derivatives. Endocrinology 1991;129(5):2361
9,11-dehydrodeoxycorticosterone 21-acetate  4780-55-6   Desoxycorticosterone/*analogs & derivatives. Arch Int Physiol Biochim 1989;97(2):175
6-hydroxy-11-deoxycorticosterone  298-65-7   Desoxycorticosterone/*analogs & derivatives. Steroids 1989;53(1-2):149
desoxycorticosterone-7-mercaptopropionic acid  121748-46-7   Desoxycorticosterone/*analogs & derivatives. Steroids 1988;51(3-4):349
desoxycortone acetate  56-47-3   Desoxycorticosterone/*analogs & derivatives. Steroids 1988;51(3-4):349
6-dehydrodeoxycorticosterone acetate  21589-90-2   Desoxycorticosterone/*analogs & derivatives. J Steroid Biochem 1985;23(5A):673
19-nordeoxycorticosterone glucosiduronate  0   Desoxycorticosterone/*analogs & derivatives. Hypertension 1985;7(3 Pt 2):I-12
9-fluorodeoxycorticosterone  3820-06-2   Desoxycorticosterone/*analogs & derivatives. J Endocrinol 1985;104(2):291
18-hydroxy-19-nordeoxycorticosterone  88542-91-0   Desoxycorticosterone/*analogs & derivatives. Biochem Int 1984;7(6):687
18-hydroxydeoxycorticosterone  379-68-0   Desoxycorticosterone/*analogs & derivatives. Biochemistry 1984;23(12):2558
19-oxo-11-deoxycorticosterone acetate  88378-35-2 Pregn-4-en-19-al, 21-(acetyloxy)-3,20-dioxo  Desoxycorticosterone/*analogs & derivatives. Steroids 1983;41(5):627
deoxycorticosterone 21-(1-imidazole)carboxylate  0   Desoxycorticosterone/*analogs & derivatives. Steroids 1982;39(1):1
deoxycorticosterone-19-oic  81309-33-3 Pregn-4-en-19-oic acid, 21-hydroxy-3,20-dioxo  Desoxycorticosterone/*analogs & derivatives. Endocrinology 1982;110(2):384
19-oxo-deoxycorticosterone  75220-37-0 Pregn-4-en-19-al, 21-hydroxy-3,20-dioxo  Desoxycorticosterone/*analogs & derivatives. Endocrinology 1982;110(2):384
deoxycorticosterone sulfate  1420-82-2   Desoxycorticosterone/*analogs & derivatives. J Clin Endocrinol Metab 1981;53(5):990
19-hydroxydeoxycorticosterone  2394-23-2   Desoxycorticosterone/*analogs & derivatives. Steroids 1980;36(5):601
deoxycorticosterone nitroxide  69081-49-8 Pregn-4-ene-3,20-dione, 21-(((2,5-dihydro-2,2,5,5-tetramethyl-1-oxy-1H-pyrrol-3-yl)carbonyl)oxy)  Desoxycorticosterone/*analogs & derivatives Spin Labels. Chem Biol Interact 1979;28(2-3):323
deoxycortone pivalate  808-48-0   Desoxycorticosterone/*analogs & derivatives. Lancet 1(8117):667;1979PERCORTEN
19-nordeoxycorticosterone  4682-70-6   Desoxycorticosterone/*analogs & derivatives. Endocrinology 103(4):1514;1978
tetrahydrodeoxycorticosterone  567-03-3   Desoxycorticosterone/*analogs & derivatives.
Pharma Action Anesthetics ; Anti-Anxiety Agents 		Ann Endocrinol (Paris) 36(2):97;1975; Appl Environ Microbiol 34(5):571;1977; J Clin Endocrinol Metab 38(2):298;1974; J Clin Endocrinol Metab 38(4):701;1974; J Steroid Biochem 7(10):837;1976; J Steroid Biochem 8(5):515;1977; Klin Wochenschr 56(Suppl 1):161;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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