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Complement C8

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Definition: A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.     
Pharmacological Action Immunologic Factors 		Other names Component 8, Complement; Complement, C8; C8, Complement; Complement Component C8 gamma Chain; Complement Component C8 gamma; Complement Component C8 beta Chain; Complement Component C8 beta; Complement Component C8 alpha Chain; Complement Component C8 alpha; Complement Component 8; Complement 8; C8 Complement
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
C8G protein, human  0   *Complement C8. Biochemistry 1994 May 3;33(17):5162-6
CD59 protein, human  101754-01-2   *Antigens, CD59 Complement C8 Erythrocyte Membrane Receptors, Complement. J Exp Med 1987;165(2):572

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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