Microbial Collagenase (definition)

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ψ ψ	Microbial Collagenase

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Definition: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.

coord IM with specific bacterium /enzymol (IM or NIM) if pertinent

Other names Collagenase, Microbial; Clostridium histolyticum Collagenase; Clostridiopeptidase A; Peptidase, Collagenase-Like; Collagenase, Clostridium histolyticum; Collagenase Like Peptidase; Nucleolysin; Collagenase-Like Peptidase; Collalysine

Substance	CAS Registry & name	Categories	Source
kappa-toxin, Clostridium perfringens	EC 3.4.24.3	Bacterial Proteins Microbial Collagenase.	Microb Pathog 2000 Feb;28(2):107-17
prolyl-leucyl-alanine hydroxamic acid	123984-21-4	*Oligopeptides Microbial Collagenase/antagonists & inhibitors.	Chem Pharm Bull (Tokyo) 1990;38(4):1007
cinnamido-2-methyl-5-oxoheptanoyl-prolyl-arginine	114563-66-5	*Dipeptides Microbial Collagenase/antagonists & inhibitors.	Biochem Biophys Res Commun 1989;159(2):426
(5-cinnamido-4-oxo-6-phenylhexanoyl)prolyl-proline	121822-29-5	*Dipeptides Microbial Collagenase/antagonists & inhibitors.	Biochem Biophys Res Commun 1989;159(2):426
type V collagen-degrading enzyme	EC 3.4.24.-	*Microbial Collagenase.	Acta Med Okayama 1986;40(3):179
iruxol	77648-56-7 Collagenase, mixt. with (R-(R,R))-2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)acetamide	Chloramphenicol Microbial Collagenase Drug Combinations.	Khirurgiia 4:113;1978; ZFA (Stuttgart) 49(17):856;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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