Definition: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
Other names Roussy-Levy Syndrome; Peroneal Muscular Atrophy; Muscular Atrophy, Peroneal; Hereditary Motor, and Sensory Neuropathy Type I; Hereditary Motor and Sensory-Neuropathy Type II; HMSN Type II; HMSN Type I; Atrophy, Muscular, Peroneal; Type IIs, HMSN; Syndrome, Roussy-Levy; Roussy Levy Syndrome; Roussy Levy Disease; Peroneal Muscular Atrophies; Muscular Atrophies, Peroneal; Hereditary Motor and Sensory Neuropathy Type II; Hereditary Areflexic Dystasias; HMSN Type Is; HMSN Type IIs; HMSN Is; HMSN IIs
