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Capillary Permeability

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Definition: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.  coord IM with endogenous substance /metab (IM) or exogenous substance /pharmacokin (IM)   
See Also Blood-Air Barrier; Blood-Aqueous Barrier; Blood-Brain Barrier; Blood-Nerve Barrier; Blood-Retinal Barrier; Blood-Testis Barrier; Capillary Leak Syndrome; Transendothelial and Transepithelial Migration 		Other names Vascular Permeability; Permeability, Microvascular; Permeability, Capillary; Microvascular Permeability; Vascular Permeabilities; Permeability, Vascular; Permeabilities, Vascular; Permeabilities, Microvascular; Permeabilities, Capillary; Microvascular Permeabilities; Capillary Permeabilities
 
SubstanceCAS Registry & nameCategoriesSource
vasoregulin  0   *Neoplasm Proteins Capillary Permeability/drug effects Vascular Neoplasms. Agents Actions 1986;17(3-4):270

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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