encyclopedia of medical concepts
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Sirtuin 1

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Definition: A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.      Other names Silent Mating Type Information Regulation 2 Homolo
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  0   *Carbazoles Sirtuin 1/antagonists & inhibitors. J Med Chem 2005 Dec 15;48(25):8045-54
Sirt1 protein, rat  EC 3.5.1.-   *Sirtuin 1. Science 2004 Jul 16;305(5682):390-2
Sirt1 protein, mouse  EC 3.5.1.-   *Sirtuin 1. Nature 2000 Feb 17;403(6771):795-800
SIRT1 protein, human  EC 3.5.1.-   *Sirtuin 1.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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