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CCN Intercellular Signaling Proteins

More information in Books or onNLM PubMed
Definition: A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.     
Examples Connective Tissue Growth Factor; Cysteine-Rich Protein 61; Nephroblastoma Overexpressed Protein 		Other names Matricellular CCN Proteins; CCN Family Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Wisp3 protein, mouse  0   *CCN Intercellular Signaling Proteins.
wisp1b protein, zebrafish  0   *CCN Intercellular Signaling Proteins.
Wisp2 protein, zebrafish  0   *Zebrafish Proteins *CCN Intercellular Signaling Proteins. Dev Dyn 2010 Jun;239(6):1755-67
wisp1a protein, zebrafish  0   *Zebrafish Proteins *CCN Intercellular Signaling Proteins. Dev Dyn 2010 Jun;239(6):1755-67
Wisp3 protein, zebrafish  0   *Zebrafish Proteins *CCN Intercellular Signaling Proteins. J Clin Invest 2007 Oct;117(10):3075-86
Wisp1 protein, mouse  0   *Proto-Oncogene Proteins *CCN Intercellular Signaling Proteins.
Wisp1 protein, rat  0   *Proto-Oncogene Proteins *CCN Intercellular Signaling Proteins.
WISP2 protein, human  0   *Repressor Proteins *CCN Intercellular Signaling Proteins. Biochem Biophys Res Commun 2000 Aug 18;275(1):108-14; J Biol Chem 1999 Jun 11;274(24):17123-31
WISP3 protein, human  0   *CCN Intercellular Signaling Proteins. Clin Cancer Res 1999 Sep;5(9):2511-
WISP1 protein, human  0   *Proto-Oncogene Proteins *CCN Intercellular Signaling Proteins. J Exp Med 1998 Feb 2;187(3):289-96; Proc Natl Acad Sci USA 1998 Dec 8;95(25):14717-22
Wisp2 protein, rat  0   *Repressor Proteins *CCN Intercellular Signaling Proteins. Mol Cell Biol 1998 Oct;18(10):6131-41

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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